Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ophthalmic Herpes simplex keratitis Age: Adult |
Dose: 0.15% gel – 1 drop Frequency: 5 times daily (approximately every 3 hours while awake) Duration: until corneal healing occurs Note: Apply in the inferior conjunctival sac of the affected eye. |
|
Indication: Ophthalmic Herpes simplex keratitis Age: Adult Condition: Maintenance |
Dose: 0.15% gel – 1 drop Frequency: three times daily Duration: 7 days after healing |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Herpes simplex keratitis Age: less than 2 years |
Dose: Ophthalmic Drop – Not applicable Note: Safety and efficacy not established |
|
Indication: Herpes simplex keratitis Age: 2 years or older |
Dose: Ophthalmic Drop – 1 drop Frequency: 5 times daily Duration: until corneal healing occurs Note: Apply in the inferior conjunctival sac of the affected eye, approximately every 3 hours while awake |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Creatinine Clearance 50-69 mL/minute |
Dose: Intravenous – 2.5 mg/kg Frequency: every 12 hours |
|
Condition: Creatinine Clearance 25-49 mL/minute |
Dose: Intravenous – 2.5 mg/kg Frequency: once daily |
Administration
- Must be diluted before IV use
- Give over designated time
Side Effect
- Blurred vision (60%)
- Eye irritation (20%)
- Punctate keratitis (5%)
- Conjunctival hyperemia (5%)
- Neutropenia w/ ANC Less than 1000/cu,mm (25-50%)
- Thrombocytopenia (20%)
- Abnl LFTs
- Anemia
- Confusion
- Headache
- Nausea/vomiting
- Neuropathy
- Paresthesia
- Pruritus
- Retinal detachment
- Rash
- Sepsis
- Weakness
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Zidovudine
|
Increased risk of haematologic toxicity
|
|
Didanosine
|
May increase serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe neutropenia
|
Risk of infection
|
|
Severe thrombocytopenia
|
Risk of bleeding
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 15°C to 30°C in a dry place protected from light. It is desirable that the contents should not be used more than one month after first opening of the tube.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.