Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Narcolepsy, Obstructive sleep apnoea Age: Adult |
Dose: Oral – 150-250 mg Frequency: once daily as a single dose in the morning or in 2 divided doses (in the morning and at midday) |
|
Indication: Shift Work Sleep Disorder |
Dose: Oral – 150 mg Frequency: once daily Note: 1 hour prior to patient's work shift |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Renal impairment: Safety and efficacy not established Note: Renal impairment: Safety and efficacy not established |
Administration
- Can be taken with or without food
- Take at the same time each day
Side Effect
- Headache (14-23%)
- Nausea (6-9%)
- Dry mouth (2-7%)
- Dizziness (5%)
- Anxiety (4%)
- Diarrhea (4%)
- Insomnia (4%)
- Rash (1-4%)
- Depression (1-3%)
- Dyspepsia (2%)
- Fatigue (2%)
- Palpitations (2%)
- Agitation (1%)
- Anorexia (1%)
- Attention disturbances (1%)
- Contact dermatitis (1%)
- Dyspnea (1%)
- Hyperhidrosis (1%)
- Nervousness (1%)
- Paresthesia (1%)
- Pyrexia (1%)
- Angioedema
- Dysphagia
- Bronchospasm
- Reversible psychosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cyclosporin, oral contraceptives
|
May increase metabolism
|
|
Warfarin, TCAs, CYP2C19 substrates (e.g. citalopram, diazepam, methsuximide, phenytoin, propranolol, sertraline)
|
May increase levels/effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Uncontrolled Hypertension
|
Risk of cardiovascular events
|
|
Cardiac Arrhythmias
|
Risk of heart rhythm problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool (below 25°C) and dry place protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.