Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is a topoisomerase I inhibitor. It works by interfering with DNA synthesis to prevent cancer cell growth. It is used to treat various types of cancer, including colorectal cancer.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Must be diluted before use • Give over recommended time • Monitor for side effects

Question 3

When should this medicine not be used?

Accepted Answer

• During pregnancy • In bowel obstruction

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Can cause severe diarrhea - early and late onset types • Monitor for dehydration and electrolyte imbalance • Risk of neutropenia - regular blood counts required • Use caution in elderly patients • Monitor liver function regularly • Risk of blood clots - watch for signs • Avoid in bowel obstruction

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Not safe during pregnancy; • May cause fetal harm; • Avoid use

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Can cause severe diarrhea - early and late onset types • Monitor for dehydration and electrolyte imbalance • Risk of neutropenia - regular blood counts required • Use caution in elderly patients • Monitor liver function regularly • Risk of blood clots - watch for signs • Avoid in bowel obstruction

Question 7

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For once-daily dosing: If you remember on the same day, take the dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 8

What should be done in case of an overdose?

Accepted Answer

• Overdose symptoms: Diarrhea, bone marrow suppression. • Treatment: Anti-diarrheal, consider G-CSF.

Question 9

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Anemia, low white blood cells, nausea, weakness, abdominal pain, vomiting, hair loss, fever, constipation, loss of appetite• What to do:- Regular blood tests as advised- Report fever immediately- Stay hydrated- Follow anti-nausea medication schedule- Avoid infection risk; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 10

What is Irotin 100 100mg/5m used for?

Accepted Answer

Irotin 100 100mg/5m (Irinotecan Hydrochloride Trihydrate) is a pharmaceutical medicine manufactured by Techno Drugs Ltd. in Bangladesh. It is primarily prescribed for Carcinoma of Colon, Carcinoma of the Rectum.

Question 11

What is the active generic component of Irotin 100?

Accepted Answer

The active ingredient in Irotin 100 is Irinotecan Hydrochloride Trihydrate, belonging to the Topoisomerase-1 Inhibitor drug class.

Question 12

What is the retail price of Irotin 100 100mg/5m in Bangladesh?

Accepted Answer

The official retail price of Irotin 100 100mg/5m (Injection) is ৳4000.00 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 13

What is the recommended dosage for Irotin 100?

Accepted Answer

Standard adult dosage: Intravenous infusion – 125 mg/m² (Days 1, 8, 15, and 22, then 2 weeks off, then repeat). Pediatric dosage: No approved pediatric dosage available. Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 14

Is Irotin 100 safe during pregnancy and breastfeeding?

Accepted Answer

Irotin 100 is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 15

What are the common side effects of Irotin 100?

Accepted Answer

**More than 10%**; Anemia (More than 90%);Leukopenia (More than 90%);Neutropenia (More than 90%);Thrombocytopenia (More than 90%);Elevated bilirubin (88%);Diarrhea (85%);Nausea (79%);Asthenia (70%);Abdominal pain (63%);V

Clinical Information	Administration Information
Indication: Metastatic Colorectal Cancer Age: Adult Condition: Monotherapy (Regimen 1 - Weekly)	Dose: Intravenous infusion – 125 mg/m² Frequency: Days 1, 8, 15, and 22, then 2 weeks off, then repeat Note: Infuse over 90 minutes. Patients should be premedicated with antiemetic agents. Atropine treatment should be considered in patients that experience cholinergic symptoms. Adjust dose per protocol. Hepatic impairment: Dose reduction may be necessary.
Indication: Metastatic Colorectal Cancer Age: Adult Condition: Monotherapy (Regimen 2 - Once Every 3 Weeks)	Dose: Intravenous infusion – 350 mg/square meter Frequency: every 3 weeks Note: Infuse over 30-90 minutes. Patients should be premedicated with antiemetic agents. Atropine treatment should be considered in patients that experience cholinergic symptoms. Adjust dose per protocol. Hepatic impairment: Dose reduction may be necessary.

Drug Name	Risk Factors
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)	Increase risks of dehydration secondary to vomiting/diarrhoea
Dexamethasone	May enhance lymphocytopenia

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources