Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Darier's disease Age: Adult |
Dose: Oral – Initially, 10 mg Frequency: daily Duration: 2-4 weeks Note: Maximum: 50 mg/day |
|
Indication: Congenital icthyosis Age: Adult |
Dose: Oral – Initially, 25-30 mg Frequency: daily Duration: 2-4 weeks Note: Dose adjustments are done after initial period |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not applicable – No approved dosage Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not specified Note: Avoid in severe impairment (increased risk of toxicity). |
Administration
- Take with main meals or with milk
- Take at the same time each day
Side Effect
- Cheilitis (More than 75%)
- Alopecia (50-75%)
- Hypertriglyceridemia (50-75%)
- Skin peeling (50-75%)
- Dry skin (25-50%)
- Dysglycemia (25-50%)
- Increased LFT (25-50%)
- Nail disorder (25-50%)
- Pruritus (25-50%)
- Rhinitis (25-50%)
- Arthralgia (10-25%)
- Changes in phosphorus, potassium, sodium & magnesium levels (10-25%)
- Dry mouth (10-25%)
- Epistaxis (10-25%)
- Erythematous rash (10-25%)
- Hepatotoxicity (10-25%)
- Hyperesthesia (10-25%)
- Paresthesia (10-25%)
- Paronychia (10-25%)
- Rigors (10-25%)
- Skin atrophy (10-25%)
- Spinal hyperostosis (10-25%)
- Sticky skin (10-25%)
- Xerophthalmia (10-25%)
- Edema
- Flushing
- Depression
- Fatigue
- Headache
- Insomnia
- Somnolence
- Abdominal pain
- Anorexia
- Diarrhea
- Gingivitis
- Increased appetite
- Nausea
- Stomatitis
- Vomiting
- Hot flashes
- Vision changes
- Corneal epithelial abnormality
- Sinusitis
- Phototoxicity
- jaundice
- hepatitis and hepatotoxity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Warfarin
|
Reduces anticoagulant effect
|
|
Methotrexate
|
Increased hepatotoxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hepatic Impairment
|
Risk of liver toxicity
|
|
Renal Impairment
|
Can worsen kidney function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place, protected from light. Do not store above 25°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.