Indication
Details coming soon
Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Waldenstrom Macroglobulinemia |
Dose: Capsules – 420 mg Frequency: once daily Note: taken by mouth once daily (three 140 mg capsules once daily) |
|
Indication: Mantle Cell Lymphoma |
Dose: Capsules – 560 mg Frequency: once daily Note: taken by mouth once daily (four 140 mg capsules once daily) |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Under 18 years |
Dose: Not recommended Note: Not recommended for use in children and adolescents under 18 years of age |
Administration
- Take at same time each day
- Take with glass of water
Side Effect
- Increased serum creatinineeatinine, 1.5 x ULN (67%)
- Platelets decreased, all grades (57%)
- Diarrhea (51%)
- Hemorrhage (48%)
- Neutrophils decreased, all grades (47%)
- Hemoglobin decreased, all grades (41%)
- Fatigue (41%)
- Musculoskeletal pain (37%)
- Peripheral edema (35%)
- URI infection (34%)
- Nausea (31%)
- Bruising (30%)
- Neutropenia, grades 3 or 4 (29%)
- Dyspnea (27%)
- Constipation (25%)
- Rash (25%)
- Abdominal pain (24%)
- Vomiting (23%)
- Decreased appetite (221%)
- Cough (19%)
- Pyrexia (18%)
- Stomatitis (17%)
- Thrombocytopenia, grades 3 or 4 (17%)
- UTI infection (14%)
- Pneumonia (14%)
- Skin infections (14%)
- Asthenia (14%)
- Muscle spasms (14%)
- Dizziness (14%)
- Sinusitis (13%)
- Headache (13%)
- Dehydration (12%)
- Dyspepsia (11%)
- Petechiae (11%)
- Arthralgia (11%)
- Epistaxis (11%)
- Platelets decreased, all grades (71%)
- Diarrhea (63%)
- Bruising (54%)
- Neutrophils decreased, all grades (54%)
- URT infection (48%)
- Hemoglobin decreased, all grades (44%)
- Fatigue (31%)
- Rash (27%)
- Musculoskeletal pain (27%)
- Neutropenia, grades 3 or 4 (27%)
- Pyrexia (25%)
- Peripheral edema (23%)
- Constipation (23%)
- Arthralgia (23%)
- Nausea (21%)
- Stomatitis (21%)
- Sinusitis (21%)
- Dizziness (21%)
- Vomiting (19%)
- Cough (19%)
- Muscle spasms (19%)
- Headache (19%)
- Skin infection (17%)
- Petechiae (17%)
- Decreased appetite (17%)
- Hypertension (17%)
- Abdominal pain (15%)
- Oropharyngeal pain (15%)
- Dyspepsia (13%)
- Asthenia (13%)
- Chills (13%)
- Anemia, grades 3 or 4 (9%)
- Increased serum creatinineeatinine, 1.5-3 x ULN (9%)
- Hemorrhage, grades 3 or 4 (5%)
- Secondary primary malignancies (5%)
- Pneumonia (10%)
- UTI (10%)
- Dyspnea (10%)
- Peripheral neuropathy (10%)
- Second malignancies (10%)
- Anxiety (10%)
- Insomnia (10%)
- Thrombocytopenia, grades 3 or 4 (10%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Strong or moderate CYP3A4 inhibitors
|
Increased exposure
|
|
Grapefruit, Seville oranges
|
Avoid as these contain moderate inhibitors of CYP3A4
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Risk of allergic reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a dry place below 30°C, protect from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.