Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Short-term management of haemorrhage Age: Adult |
Dose: Oral – 1-1.5 g or 15-25 mg/kg Frequency: twice daily or three times daily |
|
Indication: Management of hereditary angioedema Age: Adult |
Dose: Oral – 1-1.5 g Frequency: twice daily or three times daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Short-term management of haemorrhage Age: Child |
Dose: Oral – 25 mg/kg Frequency: twice daily or three times daily |
|
Indication: Management of hereditary angioedema Age: Child |
Dose: Oral – 25 mg/kg Frequency: twice daily or three times daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment with serum creatinine concentration 120-250 micromol/l |
Dose: Not specified – 15 mg/kg Frequency: twice daily Note: Adjust dose based on serum creatinine concentration |
|
Condition: Renal impairment with serum creatinine concentration 250-500 micromol/l |
Dose: Not specified – 15 mg/kg Frequency: once daily Note: Adjust dose based on serum creatinine concentration |
Administration
- Can be taken with or without food
- Take 2-3 times daily as prescribed
Side Effect
- Headache (50.4%)
- Nasal and sinus symptoms (25.4%)
- Back pain (20.7%)
- Abdominal pain (19.8%)
- Musculoskeletal pain (11.2%)
- Arthralgia (6.9%)
- Muscle cramps and spasms (5.8%)
- Migraine (6%)
- Anemia (5.6%)
- Fatigue (5.2%)
- Visual abnormalities
- Hypotension (with rapid injection)
- Nausea
- Vomiting
- Diarrhea
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Estrogens, Factor IX complex concentrates, anti-inhibitor coagulant concentrates
|
Potentially Fatal: Increased risk of thrombus formation
|
|
Tretinoin
|
Potentially Fatal: Increased risk of fatal thrombotic complications in acute promyelocytic leukaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Failure
|
Risk of accumulation
|
|
Active Intravascular Clotting
|
Risk of thrombosis
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a dry place at 15-30°C, away from light and keep out of children's reach.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.