Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ankylosing spondylitis Age: Adult |
Dose: Tablet – 100 mg Frequency: twice daily Note: Administered by mouth |
|
Indication: Osteoarthritis Age: Adult |
Dose: Tablet – 100 mg Frequency: twice daily Note: Administered by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Not applicable – Safety and efficacy not established Note: Safety and efficacy have not been established in children |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Lowest effective dose Duration: Shortest possible duration Note: Avoid if possible or use with caution; avoid in moderate to severe impairment. Monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure. |
Administration
- Take with or immediately after meals
- Take with a full glass of water
Side Effect
- Gastrointestinal disorders (dyspepsia, abdominal pain, nausea and diarrhoea) and occasional occurance of dizziness
- Dermatological side effects including pruritus and rash
- Abnormal hepatic enzyme levels and raised serum creatinineeatinine have occasionally been reported
- Severe GI bleeding
- nephrotoxicity
- blood dyscrasias
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Lithium, Digoxin
|
May increase plasma concentrations
|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene), Ciclosporin
|
Increased nephrotoxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Moderate to Severe Renal Impairment
|
Can worsen kidney function
|
|
Peptic Ulceration, GI Bleed
|
Risk of bleeding complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.