Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is an anti-inflammatory medication primarily used to treat inflammatory bowel diseases. It works by reducing inflammation in the intestines, thereby alleviating symptoms of the disease.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Can be taken with or without food • Take with a full glass of water • Swallow tablet whole without breaking or crushing • Try to take doses at evenly spaced times throughout the day

Question 3

When should this medicine not be used?

Accepted Answer

• Known hypersensitivity to mesalamine • Severe kidney problems • Known allergy to salicylates

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Use with caution in patients with pyloric stenosis as it may delay drug release in the colon • Monitor kidney function before and during treatment • Use carefully in patients with liver problems • Be cautious in patients with a history of kidney disease

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Limited data on use in pregnancy • No evidence of birth defects in animal studies • Small amounts may cross the placenta • Use only if benefits outweigh risks

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Use with caution in patients with pyloric stenosis as it may delay drug release in the colon • Monitor kidney function before and during treatment • Use carefully in patients with liver problems • Be cautious in patients with a history of kidney disease

Question 7

Is this medicine suitable for children and elderly?

Accepted Answer

• Patients over 65 years require blood count monitoring. • Kidney function evaluation is mandatory before starting. • Not safe for children under 2 years.

Question 8

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For once-daily dosing: If you remember on the same day, take the dose. • For twice-daily dosing: If there's more than 6 hours until your next dose, take the missed dose. • If you're unsure, contact your doctor or pharmacist.

Question 9

What should be done in case of an overdose?

Accepted Answer

• No specific antidote exists. • Prevent further gastrointestinal tract absorption. • Symptoms: GI discomfort, nausea, vomiting, abdominal pain. • Treatment: Symptomatic and supportive care, maintain fluid-electrolyte balance, monitor renal function.

Question 10

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Stomach pain, digestive discomfort, headache, gas, nausea, tiredness, weakness, fever, worsening of colitis, dizziness, skin rash, itching • What to do: Contact doctor immediately if severe stomach pain or fever; Stay hydrated; Take medicine with food to reduce stomach upset; Monitor for any allergic reactions; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 11

What is Mesala 400 400mg used for?

Accepted Answer

Mesala 400 400mg (5 Aminosalicylic Acid (Mesalamine/Mesalazine)) is a pharmaceutical medicine manufactured by NIPRO JMI Pharma Limited in Bangladesh. It is primarily prescribed for Crohn's Disease, Inflammatory Bowel Disease, Ulcerative Colitis, Ulcerative Proctitis.

Question 12

What is the active generic component of Mesala 400?

Accepted Answer

The active ingredient in Mesala 400 is 5 Aminosalicylic Acid (Mesalamine/Mesalazine), belonging to the Drugs For Ulcerative Colitis drug class.

Question 13

What is the retail price of Mesala 400 400mg in Bangladesh?

Accepted Answer

The official retail price of Mesala 400 400mg (Tablet) is ৳7.00 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 14

What is the recommended dosage for Mesala 400?

Accepted Answer

Standard adult dosage: Delayed Release Tablet (400 mg) – 2.4 g (daily in divided doses). Pediatric dosage: Delayed Release (DR) Tablet (400mg) – 800 mg (three times daily). Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 15

Is Mesala 400 safe during pregnancy and breastfeeding?

Accepted Answer

Mesala 400 is classified under Pregnancy Category "B". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 16

What are the common side effects of Mesala 400?

Accepted Answer

Less than pMore than **1-10%**; Abdominal pain (4-8%); GI discomfort (4-[..449/569..]ome; Hypersensitivity reactions; Hepatic failure;Less than /pMore than

Clinical Information	Administration Information
Indication: Ulcerative colitis Age: Adult Condition: Acute attack of mild to moderate ulcerative colitis	Dose: Delayed Release Tablet (400 mg) – 2.4 g Frequency: daily in divided doses
Indication: Ulcerative colitis Age: Adult Condition: Maintenance of remission of ulcerative colitis	Dose: Delayed Release Tablet (400 mg) – 1.2–2.4 g Frequency: daily in divided doses

Clinical Information	Administration Information
Indication: Ulcerative colitis Condition: Acute attack (mild to moderate)	Dose: Delayed Release (DR) Tablet (400mg) – 800 mg Frequency: three times daily
Indication: Ulcerative colitis Condition: Maintenance of remission	Dose: Delayed Release (DR) Tablet (400mg) – 400–800 mg Frequency: two to three times daily

Clinical Information	Administration Information
Condition: Renal impairment with Creatinine Clearance less than 20 ml/min	Dose: dosage form not mentioned – dose not mentioned Note: Avoid
Condition: Renal function deteriorates while in therapy	Dose: dosage form not mentioned – dose not mentioned Note: Discontinue use

Drug Name	Risk Factors
Lactulose	Prevents release of mesalazine
Digoxin	May decrease absorption

Disease Name	Risk Factors
Severe Renal Impairment	GFR less than 30 mL per minute Monitor for general drug reactions can cause further kidney damage
Severe Liver Impairment	Can worsen liver function

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

Is this medicine suitable for children and elderly?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources