Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: Adult
Dose: Oral – Initially 80 mg, may be increased to 160 mg
Frequency: once daily
Note: Maximum dose: 320 mg once daily.
Indication: Heart failure
Age: Adult
Dose: Oral – Initially 40 mg
Frequency: twice daily
Note: May be increased to 160 mg twice daily if tolerated.

Child Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: greater than 6 years
Dose: Tablet – Initially, 40 mg
Frequency: once daily
Note: Maximum: 80 mg once daily
Indication: Hypertension
Age: greater than 6 years
Dose: Tablet – Initially, 80 mg
Frequency: once daily
Note: Maximum: 160 mg once daily

Renal Dose

Clinical InformationAdministration Information
Age: Adult
Condition: Renal impairment CrCl greater than 30 mL/min
Dose: Not specified – Not specified
Note: No dose adjustment necessary
Age: Adult
Condition: Renal impairment CrCl less than 30 mL/min
Dose: Not specified – Not specified
Note: Use with caution
Administration
  • Can be taken with or without food
  • Take at same time each day
Side Effect

Drug Interaction

Drug NameRisk Factors
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
May antagonise hypotensive effects and increase the risk of renal impairment
Potassium-sparing diuretics (Amiloride, Eplerenone, Spironolactone, Triamterene), K supplements, K-containing salt substitutes
Increased risk of hyperkalaemia

Disease Interaction

Disease NameRisk Factors
Severe Hepatic Impairment
Risk of drug accumulation
Cirrhosis, Biliary Obstruction
Impaired drug metabolism

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C. Protect from moisture and heat.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.