Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – Initially 80 mg, may be increased to 160 mg Frequency: once daily Note: Maximum dose: 320 mg once daily. |
|
Indication: Heart failure Age: Adult |
Dose: Oral – Initially 40 mg Frequency: twice daily Note: May be increased to 160 mg twice daily if tolerated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: greater than 6 years |
Dose: Tablet – Initially, 40 mg Frequency: once daily Note: Maximum: 80 mg once daily |
|
Indication: Hypertension Age: greater than 6 years |
Dose: Tablet – Initially, 80 mg Frequency: once daily Note: Maximum: 160 mg once daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment CrCl greater than 30 mL/min |
Dose: Not specified – Not specified Note: No dose adjustment necessary |
|
Age: Adult Condition: Renal impairment CrCl less than 30 mL/min |
Dose: Not specified – Not specified Note: Use with caution |
Administration
- Can be taken with or without food
- Take at same time each day
Side Effect
- Dizziness (17%, heart failure)
- Increased blood urea nitrogen (BUN, 17%)
- Hyperkalemia (4-10%)
- Dizziness (2-8%
- hypertension)
- Hypotension (1-7%
- heart failure)
- Fatigue (3%)
- Viral infection (3%)
- Neutropenia (2%)
- Syncope (More than 1%)
- Upper abdominal pain (More than 1%)
- Vertigo (More than 1%)
- Headache
- Cough (rare)
- Blood dyscrasias (eg neutropenia)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
May antagonise hypotensive effects and increase the risk of renal impairment
|
|
Potassium-sparing diuretics (Amiloride, Eplerenone, Spironolactone, Triamterene), K supplements, K-containing salt substitutes
|
Increased risk of hyperkalaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Impairment
|
Risk of drug accumulation
|
|
Cirrhosis, Biliary Obstruction
|
Impaired drug metabolism
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C. Protect from moisture and heat.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.