Medicine Overview

Indication
Know Medicine, Follow Guideline

Adult Dose
Clinical InformationAdministration Information
Indication: Schizophrenia
Age: Adult
Dose: Oral – Initially, 6 mg
Frequency: once daily in the morning
Note: May be titrated upward or downward in increments of 3 mg/day at intervals greater than 5 days; not to exceed 12 mg/day
Indication: Schizoaffective Disorder
Age: Adult
Condition: Monotherapy or as an adjunct to mood stabilizers or antidepressants
Dose: Oral – 6 mg
Frequency: once daily in the morning
Note: Range 3-12 mg; titration may not be necessary; if exceeding 6 mg/day, increases of 3 mg/day recommended at intervals of 4 days or more; not to exceed 12 mg/day

Child Dose
Clinical InformationAdministration Information
Indication: Schizophrenia
Age: less than 12 years
Dose: Not established
Note: Safety and efficacy not established
Indication: Schizophrenia
Age: greater than 12 years
Dose: Oral – 3 mg/day initially
Note: May be increased if necessary in increments of 3 mg/day at intervals greater than or equal to 5 days; not to exceed 6 mg/day

Renal Dose
Clinical InformationAdministration Information
Condition: Renal impairment creatinine clearance 50-79 mL/minute
Dose: Not specified – 3 mg/day initially
Frequency: once daily
Note: not to exceed 6 mg/day
Condition: Renal impairment creatinine clearance 10-49 mL/minute
Dose: Not specified – 1.5 mg/day initially
Frequency: once daily
Note: not to exceed 3 mg/day
Administration
  • Can be taken with or without food
  • Take at same time each day
Side Effect

Drug Interaction
Drug NameRisk Factors
Class IA (e.g. quinidine, disopyramide) or class III (e.g. amiodarone, sotalol) Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide)
Increased risk of QT prolongation
Other Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), tricyclics
Additive effects with drugs that cause orthostatic hypotension

Disease Interaction
Disease NameRisk Factors
Hypersensitivity
Risk of allergic reactions

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, away from light. Keep out of reach of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.