Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Angina Age: Adult |
Dose: Conventional tablet – 30 mg Frequency: every 6 hours by mouth Note: increased every 1 or 2 days until angina controlled (usually 180-360 mg/day by mouth divided every 6-8 hours); not to exceed 360 mg/day |
|
Indication: Angina Age: Adult |
Dose: Sustained Release – 120 mg/day Frequency: by mouth Note: titrate after 7-14 days; maintenance range usually 120-320 mg/day; not to exceed 540 mg/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Not applicable – No approved pediatric dosage available Note: Not recommended for pediatric use |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Not mentioned Note: Use caution |
Administration
- May be taken with or without food
- Swallow whole with water
Side Effect
- Edema (2-15%)
- Headache (5-12%)
- Dizziness (3-10%)
- AV block (2-8%)
- Peripheral edema (2-8%)
- Bradyarrhythmia (2-6%)
- Headache (1-5%)
- Hypotension (2-4%)
- Nausea (3%)
- Vomiting (2%)
- Vasodilation (2-3%)
- Extrasystoles (2%)
- Flushing (1-2%)
- Drug-induced gingival hyperplasia (Less than 2%)
- Myalgia (2%)
- Diarrhea (1-2%)
- Constipation (2-4%)
- Bronchitis (1-4%)
- Sinus congestion (1-2%)
- Dyspnea (1-6%)
- Congestion (1-2%)
- Increased Alkaline phosphatase as well as ALT and AST
- CHF
- Thrombocytopenia
- Toxic epidermal necrolysis
- Hemolytic anemia
- Photosensitivity
- Extrapyramidal symptoms
- Syncope
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Clonidine
|
Increased AV blocking effect
|
|
Statins (Atorvastatin, Simvastatin, Rosuvastatin, Pravastatin, Lovastatin, Fluvastatin) (e.g. atorvastatin, lovastatin), Carbamazepine, Phenytoin
|
May increase serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Sick Sinus Syndrome
|
Can worsen heart rhythm
|
|
Heart Block
|
Can worsen conduction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.