Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to severe pain Age: Adult Condition: Non-opioid-tolerant patients |
Dose: Intramuscular, Intravenous, or Subcutaneous Injection – 10-20 mg Frequency: every 3-6 hours as required Note: Maximum single dose: 20 mg. Maximum daily dose: 160 mg. |
|
Indication: Adjunct in balanced anesthesia Age: Adult Condition: Induction |
Dose: Intravenous Injection – 0.3-3 mg/kg Duration: administered over 10-15 minutes |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Pain Age: less than 1 year |
Dose: Injection – Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Pain Age: greater than 1 year |
Dose: Intravenous/Intramuscular/Subcutaneous – 0.1-0.2 mg/kg Frequency: every 3-4 hours as needed Note: individual dose not to exceed 20 mg; not to exceed 160 mg/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose: Note: Caution; dose reduction may be necessary; monitor |
Administration
- For IV administration only
- Give each 10mg over 3-5 minutes
Side Effect
- Sedation (36%)
- Clamminess (9%)
- Nausea and vomiting (6%)
- Dizziness (5%)
- Xerostomia (4%)
- Headache (3%)
- Asthma
- Bradycardia
- Burning
- Dyspnea
- Hypertension
- Hypotension
- Itching
- Miosis
- Pulmonary edema
- Respiratory depression
- Tachycardia
- Urticaria
- Vertigo
- shock
- respiratory distress
- respiratory arrest
- bradycardia
- cardiac arrest
- hypotension
- laryngeal oedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Alcohol, Anaesthetics, Anxiolytics, Hypnotics, TCAs, Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole)
|
Additive CNS depressant effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Risk of severe allergic reactions
|
|
Toxin-Associated Diarrhea
|
Can worsen condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep it in a cool and dry place, protected from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.