Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Rheumatoid Arthritis Age: Adult |
Dose: Tablet – 5 mg Frequency: twice daily Note: Hepatic impairment Mild: No dosage adjustment required; Moderate: Not to exceed 5 mg once daily; Severe: Not recommended |
|
Indication: Rheumatoid Arthritis Age: Adult |
Dose: Extended-release tablet – 11 mg Frequency: once daily Note: Hepatic impairment Mild: No dosage adjustment required; Moderate: Not to exceed 5 mg once daily; Severe: Not recommended |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild renal impairment |
Dose: - Note: No dosage adjustment required |
|
Condition: Moderate-to-severe renal impairment |
Dose: - 5 mg Frequency: once daily Note: Not to exceed 5 mg once daily |
Administration
- Can be taken with or without food
- Do not start if blood lymphocyte count is below 500 cells/mm3
Side Effect
- Overall infections (20-22%)
- URTI (4.5%)
- Headache (4.3%)
- Diarrhea (4%)
- Nasopharyngitis (3.8%)
- UTI (2%)
- Hypertension (1.6%)
- ANC Less than 500/mm³ (0.07%)
- Lymphocytes Less than 500/mm³ (0.04%)
- Serious infections 1.7 events per 100 patient-years
- Malignancies 0.3 events per 100 patient-years
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Potent CYP3A4 inhibitors (e.g. ketoconazole), moderate CYP3A4 inhibitors & potent CYP2C19 inhibitors (e.g. fluconazole)
|
Increased exposure
|
|
Potent CYP inducers (e.g. rifampin)
|
Decreased exposure
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.