Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Acute Lymphoblastic Leukemia
Age: Adult
Condition: Relapsed or refractory Philadelphia chromosome positive (Ph+)
Dose: Tablet – 600 mg
Frequency: once daily
Note: Administered by mouth
Indication: Myelodysplastic/Myeloproliferative Diseases
Age: Adult
Condition: Associated with platelet-derived growth factor receptor gene re-arrangements as determined with an FDA-approved test
Dose: Tablet – 400 mg
Frequency: once daily
Note: Administered by mouth

Child Dose

Clinical InformationAdministration Information
Indication: Chronic Myeloid Leukemia
Age: less than 1 year
Condition: newly diagnosed Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase
Dose: PO – Not established
Note: Safety and efficacy not established
Indication: Chronic Myeloid Leukemia
Age: greater than 1 year
Condition: newly diagnosed Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase
Dose: PO – 340 mg/m²/day
Note: Not to exceed 600 mg/day; by mouth (oral)
Administration
  • Take with food
  • Take with large glass of water
Side Effect

Drug Interaction

Drug NameRisk Factors
Azole Antifungals (Fluconazole, Itraconazole, Ketoconazole, Voriconazole, Posaconazole), Macrolide Antibiotics (Erythromycin, Clarithromycin, Azithromycin)
Increased serum levels
Carbamazepine, Dexamethasone, Phenobarbital, Phenytoin, Rifampicin
Reduced serum levels

Disease Interaction

Disease NameRisk Factors
No specific contraindications listed
Monitor for general drug reactions

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30° C. Protect from moisture.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.