Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute Lymphoblastic Leukemia Age: Adult Condition: Relapsed or refractory Philadelphia chromosome positive (Ph+) |
Dose: Tablet – 600 mg Frequency: once daily Note: Administered by mouth |
|
Indication: Myelodysplastic/Myeloproliferative Diseases Age: Adult Condition: Associated with platelet-derived growth factor receptor gene re-arrangements as determined with an FDA-approved test |
Dose: Tablet – 400 mg Frequency: once daily Note: Administered by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Myeloid Leukemia Age: less than 1 year Condition: newly diagnosed Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase |
Dose: PO – Not established Note: Safety and efficacy not established |
|
Indication: Chronic Myeloid Leukemia Age: greater than 1 year Condition: newly diagnosed Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase |
Dose: PO – 340 mg/m²/day Note: Not to exceed 600 mg/day; by mouth (oral) |
Administration
- Take with food
- Take with large glass of water
Side Effect
- Edema (53%)
- Neutropenia (Grade 3 7-27%, Grade 4 3-48%)
- Nausea (43%)
- Muscle cramps (35%)
- Musculoskeletal pain (34%)
- Thrombocytopenia (Grade 3 1-31%, Grade 4 1-34%)
- Rash (32%)
- Fatigue (31%)
- Diarrhea (30%)
- Headache (29%)
- Arthralgia (27%)
- Abd pain (23%)
- Myalgia (21%)
- Nasopharyngitis (19%)
- Hemorrhage (19%)
- Vomiting (15%)
- Dyspepsia (15%)
- Cough (13%)
- Dizziness (13%)
- URT infection (13%)
- Fever (12%)
- Weight gain (12%)
- Hepatotoxicity (6-12%)
- Insomnia (11%)
- Flushing
- Palpitation
- Dry skin
- Erythema
- Metabolic hyperglycemia
- Stomatitis/mucositis
- Lymphopenia
- Aplastic anemia
- Atrial fibrillation
- Avascular necrosis
- Cardiac failure
- Cardiogenic shock
- Embolism
- Eosinophilia
- Hepatotoxicity
- cerebral oedema
- increased intracranial pressure
- papilloedema
- Severe fluid retention resulting in pleural and pericardial effusion
- pulmonary oedema and ascites
- Rarely
- GI perforation
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Azole Antifungals (Fluconazole, Itraconazole, Ketoconazole, Voriconazole, Posaconazole), Macrolide Antibiotics (Erythromycin, Clarithromycin, Azithromycin)
|
Increased serum levels
|
|
Carbamazepine, Dexamethasone, Phenobarbital, Phenytoin, Rifampicin
|
Reduced serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30° C. Protect from moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.