Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Epilepsy Age: Adult |
Dose: Oral – Initially, 1 mg Frequency: once daily at night Duration: for 4 days, gradually increased over 2-4 weeks Note: Maintenance: 4-8 mg/day. Maximum: 20 mg/day. |
|
Indication: Panic disorder Age: Adult |
Dose: Oral – Initially, 0.25 mg Frequency: twice daily Note: Increased after 3 days up to 1 mg/day. Maximum: 4 mg/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Epilepsy Age: Child: less than 10 years Condition: Initial |
Dose: Oral – 0.01-0.03 mg/kg/day Frequency: 2 or 3 divided doses Note: by mouth (oral); not to exceed 0.05 mg/kg/day; may be increased by no more than 0.25-0.5 mg every 3rd day until seizure control is achieved |
|
Indication: Epilepsy Age: Child: less than 10 years Condition: Maintenance |
Dose: Oral – 0.1-0.2 mg/kg/day Frequency: 3 times daily Note: by mouth (oral); Maximum: 0.2 mg/kg/day |
Administration
- Can be taken with or without food
- Take at regular times
Side Effect
- Somnolence (37%)
- Abnormal coordination (5-10%)
- Ataxia (5-10%)
- Depression (5-10%)
- Dizziness (5-10%)
- Fatigue (5-10%)
- Memory impairment (5-10%)
- Upper respiratory infection (5-10%)
- Confusion (1-5%)
- Dysarthria (1-5%)
- Rhinitis (1-5%)
- Coughing (1-5%)
- Urinary frequency (1-5%)
- Impotence (1-5%)
- Decreased libido (1-5%)
- Increased salivation
- Worsening tonic-clonic seizures
- Salivary or bronchial hypersecretion leading to respiratory problems (children)
- May produce diminished reflexes or coma
- Rarely
- blood dyscrasias
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
TCAs, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), Sedatives, Hypnotics, Barbiturates, Anxiolytics, Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), Opiate agonists
|
Additive depressant effect
|
|
Phenytoin
|
May increase serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Pulmonary Insufficiency
|
Can cause dangerous respiratory depression
|
|
Acute Narrow Angle Glaucoma
|
Can increase eye pressure dangerously
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.