Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – 150 mg Frequency: once daily Note: May increase to 300 mg once daily if needed. |
|
Indication: Hypertension Age: Adult Condition: Intravascular volume depletion |
Dose: Oral – 75 mg Frequency: once daily Note: Initial dose. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: less than 6 years |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Hypertension Age: 6-12 years |
Dose: Oral – 75 mg/day Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Haemodialysis |
Dose: Not specified – 75 mg Frequency: once daily |
|
Condition: Mild-to-severe renal impairment |
Dose: Not specified – Dosage adjustment not necessary Note: unless patient is hypovolemic |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Hyperkalemia (19%)
- Dizziness (10%)
- Upper respiratory tract infection (URTI) (URTI) (9%)
- Orthostatic hypotension (5%)
- Fatigue (4%)
- Diarrhea (3%)
- Dyspepsia (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
May antagonise hypotensive effect and increase risk of nephrotoxicity
|
|
Lithium
|
May increase serum lithium levels and toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
High Blood Pressure, Heart Disease
|
May cause dangerous drop in blood pressure and kidney problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.