Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prophylaxis of skeletal events in patients with breast cancer and bone metastases Age: Adult |
Dose: Oral – 50 mg Frequency: once daily |
|
Indication: Postmenopausal osteoporosis; Prophylaxis of postmenopausal osteoporosis Age: Adult |
Dose: Oral – 150 mg Frequency: once monthly on the same date each month Note: Missed once-monthly dose: If next scheduled dose is greater than 7 days away: Take dose the next morning and return to original schedule; if next dose is less than 7 days away: Wait until the next scheduled dose; 2 tablets must not be taken within the same week |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Form – Not specified Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prophylaxis of skeletal events in patients with breast cancer and bone metastases Condition: Renal impairment with Creatinine Clearance less than 30 ml/min |
Dose: Oral – 50 mg Frequency: once weekly |
|
Indication: Prophylaxis of skeletal events in patients with breast cancer and bone metastases Condition: Renal impairment with Creatinine Clearance 30-49 ml/min |
Dose: Oral – 50 mg Frequency: every other day |
Administration
- Take on empty stomach
- Take with full glass water
Side Effect
- myalgia
- arthralgia
- fever
- chills
- fatigue
- nausea
- loss of appetite
- bone pain)
- atypical fractures
- osteonecrosis of the jaw
- ocular inflammation
- acute renal failure
- hypocalcaemia
- musculoskeletal pain
- Rarely
- anaemia
- bronchospasm
- taste disturbance
- paraesthesia
- uraemia
- transient fever (IV)
- abdominal pain
- dyspepsia
- severe oesophageal reactions (oral)
- Anaphylactic reaction/shock
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ca supplements, antacids, multivalent cation drugs
|
Decreased absorption
|
|
Aspirin, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
Increased incidence of GI irritation
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Impairment
|
Can cause kidney damage
|
|
Uncorrected Hypocalcaemia
|
Can worsen calcium imbalance
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.