Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis C Age: Adult Condition: Patients without cirrhosis or with compensated cirrhosis (Child-Pugh A) |
Dose: Tablet – 400 mg sofosbuvir/ 100 mg velpatasvir Frequency: once daily Duration: 12 weeks Note: No dosage adjustment required for mild hepatic impairment (Child-Pugh A). |
|
Indication: Chronic Hepatitis C Age: Adult Condition: Patients with decompensated cirrhosis (Child-Pugh B or C) |
Dose: Tablet – 400 mg sofosbuvir/ 100 mg velpatasvir Frequency: once daily Duration: 12 weeks Note: Administer with weight-based ribavirin and food. No dosage adjustment required for moderate or severe hepatic impairment (Child-Pugh B or C). |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment (eGFR less than 30 mL/min/1.73 m²) or End Stage Renal Disease |
Dose: Tablet – No dosage recommendation Note: No dosage recommendation can be given owing to higher exposures (up to 20-fold) of the predominant sofosbuvir metabolite |
Administration
- Can be taken with or without food
- Take at the same time each day
Side Effect
- Headache (22%)
- Fatigue (15%)
- Fatigue (32%)
- Anemia (26%)
- Hemoglobin Less than 10 g/dL (23%)
- Nausea (15%)
- Headache 11%)
- Insomnia (11%)
- Nausea (9%)
- Asthenia (5%)
- Insomnia (5%)
- Lipase increase More than 3 x ULN (3%)
- Rash (2%)
- Depression (1%)
- Increased creatinine kinase More than 10 x ULN (1%)
- Diarrhea (10%)
- Hemoglobin Less than 3.5 g/dL (7%)
- Rash (5%)
- Increased creatinine kinase ≥10 x ULN (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Drugs that increase gastric pH
|
Expected to decrease velpatasvir serum concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place (preferably below 30° C). Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.