Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic lymphocytic leukaemia Age: Adult Condition: In combination with chlorambucil, Cycle 1, Day 1 |
Dose: Intravenous – 100 mg Frequency: at 25 mg/hour Duration: over 4 hours Note: Pre-medicate with intravenous corticosteroid, oral analgesic (e.g. acetaminophen)/antipyretics and antihistamine. In case of toxicity, modify dose according to product literature. |
|
Indication: Chronic lymphocytic leukaemia Age: Adult Condition: In combination with chlorambucil, Cycle 1, Day 2 |
Dose: Intravenous – 900 mg Frequency: at 25-50 mg/hour, increased by 50 mg/hour every 30 minutes Note: Maximum rate of 400 mg/hour. Pre-medicate with intravenous corticosteroid, oral analgesic (e.g. acetaminophen)/antipyretics and antihistamine. In case of toxicity, modify dose according to product literature. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Given as IV infusion
- Must be administered by healthcare professionals
Side Effect
- Infusion related reactions (69%)
- Neutropenia (33%)
- Hypocalcemia (32%)
- Hyperkalemia (31%)
- Hyponatremia (29%)
- Creatinine increased (28%)
- AST/SGOT increased (28%)
- AST/SGPT increased (25%)
- Hypoalbuminemia (16%)
- Alkaline phosphatase increased (16%)
- Thrombocytopenia (15%)
- Hypokalemia (13%)
- Anemia (12%)
- Pyrexia (10%)
- Cough (10%)
- Leukopenia (7%)
- Tumor lysis syndrome (2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
|
May increase risk of hypotension
|
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Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), platelet inhibitors
|
May increase risk of haemorrhage
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Serum sickness
|
Can cause severe immune reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store vials in a refrigerator at 2°C-8°C. Keep vial in the outer carton in order to protect from light. Do not freeze. Do not shake.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.