Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate to severe dementia in Alzheimer's disease Age: Adult Condition: Initially |
Dose: Oral - 5 mg Frequency: once daily Duration: for the 1st week Note: As hydrochloride. Give in the morning. |
|
Indication: Moderate to severe dementia in Alzheimer's disease Age: Adult Condition: Titration Step |
Dose: Oral - 5 mg Frequency: once daily Duration: increase dose weekly in steps of 5 mg Note: Maximum: 20 mg daily. Wait for at least 1 week between dose changes. Doses greater than 10 mg/day should be given in 2 divided doses. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance 5-29 ml/min |
Dose: Dosage – 10 mg Frequency: once daily Note: Maximum: 10 mg daily. |
|
Condition: Renal impairment: Creatinine Clearance 30-49 ml/min |
Dose: Dosage – 10 mg Frequency: once daily Note: After initial dose of 5 mg daily, if well tolerated for at least 7 days, may increase to 20 mg daily. |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Dizziness (7%)
- Confusion (6%)
- Headache (6%)
- Constipation (5%)
- Cough (4%)
- Hypertension (4%)
- Backache (3%)
- Pain (3%)
- Somnolence (3%)
- Syncope (3%)
- Vomiting (3%)
- Dyspnea (2%)
- Fatigue (2%)
- Acute renal failure
- Cerebral infarction
- Cerebrovascular accident
- Deep vein thrombosis (DVT)
- Hepatitis
- liver failure
- Intracranial hemorrhage
- Neuroleptic malignant syndrome
- Seizure (including grand mal)
- Stevens-Johnson syndrome
- Transient ischemic attack
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antimuscarinics (Atropine, Hyoscine, Ipratropium), Dopaminergics
|
May increase effects
|
|
Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), Barbiturates
|
May reduce effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe renal impairment
|
Risk of drug accumulation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light. Keep this medication out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.