Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Heart Failure Condition: Reduced ejection fraction (NYHA class II-IV) |
Dose: Oral Tablet – 49 mg/51 mg Frequency: twice daily Note: Recommended starting dose. Indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure. |
|
Indication: Heart Failure Condition: Reduced ejection fraction (NYHA class II-IV) |
Dose: Oral Tablet – 97 mg/103 mg Frequency: twice daily Note: Target maintenance dose. After 2-4 weeks, double the dose to the target maintenance dose as tolerated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Symptomatic heart failure with systemic left ventricular systolic dysfunction Age: 1 year and older |
Dose: Oral – 1.6 mg/kg (starting), 2.3 mg/kg (second), 3.1 mg/kg (final) Frequency: Twice daily Note: by mouth (oral) |
|
Indication: Symptomatic heart failure with systemic left ventricular systolic dysfunction Age: 1 year and older |
Dose: Oral – 24/26 mg (starting), 49/51 mg (second), 72/78 mg (final) Frequency: Twice daily Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Mild-to-moderate (eGFR greater than or equal to 30 mL/min/1.73 m²) |
Dose: Not specified Note: No starting dose adjustment required |
|
Condition: Renal impairment Severe (eGFR less than 30 mL/min/1.73 m²) |
Dose: Tablet – 24 mg/26 mg Frequency: twice daily Note: Reduce starting dose to 24 mg/26 mg twice daily; double the dose every 2-4 weeks to target maintenance dose of 97 mg/103 mg twice daily as tolerated |
Administration
- Can be taken with or without food
- Take at regular intervals
Side Effect
- Hypotension (18%)
- Hyperkalemia (12%)
- Cough (9%)
- Dizziness (6%)
- Orthostasis (2.1%)
- Falls (1.9%)
- Angioedema, all patients (0.5%), in black patients (2.4%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Angioedema
|
Risk of life-threatening swelling
|
|
Concurrent ACE Inhibitor Use
|
Risk of severe angioedema
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at room temperature between 20°C to 25°C. Protect from moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.