Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Alzheimer Disease Age: Adult |
Dose: by mouth – 4 mg Frequency: every 12 hours Note: Initial dose |
|
Indication: Alzheimer Disease Age: Adult |
Dose: by mouth – 8-12 mg Frequency: every 12 hours Note: Maintenance dose; titrate by 4 mg every 12 hours at no less than 4 week intervals |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – Not recommended Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Moderate Renal Impairment |
Dose: Not to exceed 16 mg/day Note: Renal impairment moderate: not to exceed 16 mg/day |
|
Condition: Severe Renal Impairment (CrCl less than 9 mL/min) |
Dose: Not recommended Note: Renal impairment severe (Creatinine Clearance less than 9 mL/min): not recommended |
Administration
- Take with food
- Take in morning
Side Effect
- Nausea (20-25%)
- Diarrhea (11-15%)
- Vomiting (11-15%)
- Abdominal pain
- Anorexia
- Muscle cramp
- Fatigue
- Dizziness
- Headache
- Weight loss
- Depression
- Insomnia
- UTI
- Somnolence
- Anemia
- Syncope
- Bradycardia
- CV effects
- convulsion
- delirium
- rectal haemorrhage
- thrombocytopenia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP2D6 inhibitors (e.g. quinidine, fluoxetine, fluvoxamine, paroxetine), CYP3A4 inhibitors (e.g. ketoconazole, ritonavir)
|
Increased serum concentrations
|
|
Cimetidine
|
May increase bioavailability
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Liver Or Kidney Dysfunction
|
Can cause toxic accumulation
|
|
Disorders Of Galactose Metabolism
|
Can worsen metabolic complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.