Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Alzheimer Disease
Age: Adult
Dose: by mouth – 4 mg
Frequency: every 12 hours
Note: Initial dose
Indication: Alzheimer Disease
Age: Adult
Dose: by mouth – 8-12 mg
Frequency: every 12 hours
Note: Maintenance dose; titrate by 4 mg every 12 hours at no less than 4 week intervals

Child Dose

Clinical InformationAdministration Information
Age: Child
Dose: Tablet – Not recommended
Note: Not recommended

Renal Dose

Clinical InformationAdministration Information
Condition: Moderate Renal Impairment
Dose: Not to exceed 16 mg/day
Note: Renal impairment moderate: not to exceed 16 mg/day
Condition: Severe Renal Impairment (CrCl less than 9 mL/min)
Dose: Not recommended
Note: Renal impairment severe (Creatinine Clearance less than 9 mL/min): not recommended
Administration
  • Take with food
  • Take in morning
Side Effect

Drug Interaction

Drug NameRisk Factors
CYP2D6 inhibitors (e.g. quinidine, fluoxetine, fluvoxamine, paroxetine), CYP3A4 inhibitors (e.g. ketoconazole, ritonavir)
Increased serum concentrations
Cimetidine
May increase bioavailability

Disease Interaction

Disease NameRisk Factors
Severe Liver Or Kidney Dysfunction
Can cause toxic accumulation
Disorders Of Galactose Metabolism
Can worsen metabolic complications

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Protect from light.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.