Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Gastro-oesophageal reflux disease Age: Adult |
Dose: Oral – 20 mg Frequency: once daily in the morning Duration: 4-8 weeks Note: Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed. |
|
Indication: Gastro-oesophageal reflux disease Age: Adult Condition: Maintenance |
Dose: Oral – 10 or 20 mg Frequency: once daily in the morning Note: Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 1 year |
Dose: Delayed-release capsule (sprinkles) – Safety and efficacy not established Note: Safety and efficacy not established |
|
Age: 1-11 years |
Dose: Delayed-release capsule (sprinkles) – 5 mg Frequency: once daily Duration: for up to 12 weeks Note: by mouth (oral) 30 minutes before a meal; may increase to 10 mg/day if inadequate response |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment |
Dose: Tablet – Fixed dose Note: Renal impairment: No dosage adjustment needed. |
Administration
- Can be taken with or without meals
- Take at same time daily
Side Effect
- Headache (2-10%)
- Constipation (2%)
- Diarrhea (2-5%)
- Flatulence (3%)
- Pain (3%)
- Pharyngitis (3%)
- Abdominal pain (4%) Less than 1% Agitation
- Agranulocytosis
- Alopecia
- Anemia
- Angioedema
- Chest pain
- Delirium
- Erythema
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Jaundice
- Leukocytosis
- Leukopenia
- Migraine
- Osteoporosis related fracture
- Rhabdomyolysis
- Stevens-Johnson syndrome
- Sudden death
- Toxic epidermal necrolysis
- Abnormal taste
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ketoconazole, Itraconazole, Clopidogrel
|
May decrease serum concentration
|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene), Digoxin
|
Increased risk of hypomagnesaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Can cause severe allergic reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.