Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Intravenous Heparin overdosage Age: Adult |
Dose: Intravenous – 1-1.5 mg per 100 USP units of heparin Note: Not to exceed 50 mg. Monitor activated partial thromboplastin time 5-15 minutes after dose then in 2-8 hours. In accidental overdoses of heparin, consider half-life heparin 60-90 minutes. In setting without bleeding complications, consider observation, rather than reversal of anticoagulation with protamine (avoids adverse drug reactions). Complex of protamine and heparin may degrade over time requiring further doses. |
|
Indication: Dalteparin or Tinzaparin Overdose |
Dose: Injection – 1 mg protamine for 100 units dalteparin or tinzaparin Note: If partial thromboplastin time prolonged 4 hours after protamine overdose administer 0.5 mg per 100 units of dalteparin or tinzaparin. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- For IV use only
- Must be injected slowly over 1-3 minutes
Side Effect
- Anaphylaxis
- Hypotension
- N/V
- Decreased O2 consumption
- Flushing
- Pulmonary hypertension
- Uncontrollable bleeding
- Circulatory collapse
- Pulmonary edema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C. Do not freeze.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.