Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Tablet – pioglitazone 15 mg and metformin 500 mg Frequency: twice daily Note: Initially, 15 mg/500 mg twice daily. Maximum: Pioglitazone 45 mg and metformin 2,550 mg daily. Hepatic impairment: Contraindicated. |
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Tablet – pioglitazone 15 mg and metformin 850 mg Frequency: once daily Note: Initially, 15 mg/850 mg once daily. Maximum: Pioglitazone 45 mg and metformin 2,550 mg daily. Hepatic impairment: Contraindicated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Dose: Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: eGFR less than 30 mL/min/1.73 m² Condition: Renal impairment |
Dose: Metformin – Not specified Note: Contraindicated; If eGFR falls below 30 mL/min/1.73 m² while taking metformin, discontinue the drug |
|
Indication: eGFR 30-45 mL/min/1.73 m² Condition: Renal impairment |
Dose: Metformin – Not specified Note: Not recommended to initiate treatment; Monitor eGFR at least annually or more often for those at risk for renal impairment (e.g., elderly) |
Administration
- Take with meals
- Take at the same time each day
Side Effect
- Lower limb edema (2.9-11.3%)
- Upper respiratory infection (12-16)
- Weight gain (2.9-6.7%)
- Diarrhea (4.8-5.8%)
- Nausea (3.6-5.8%)
- Urinary Tract Infection (UTI) (5.3-5.8%)
- Dizziness (4.8-5.4%)
- Headache (4.6-5.3%)
- Sinusitis (4.4-5%)
- Edema (3%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Same as Metformin Hydrochloride
|
Same effects as Metformin Hydrochloride
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Renal Disease/Dysfunction
|
Impairs drug clearance
|
|
Cardiovascular Collapse
|
Risk of tissue hypoxia
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Protect from light and moisture. Keep out of the reach of the children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.