Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral Amlodipine component – 2.5-10 mg Frequency: once daily Note: Titrate dose gradually according to response. |
|
Indication: Hypertension Age: Adult |
Dose: Oral benazepril component – 10-40 mg Frequency: once daily Note: Titrate dose gradually according to response. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Paediatric |
Dose: Tablet – Dosage not established Note: Safety and efficacy in paediatric patients have not been established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose – Decrease dose Note: Decrease dose if creatinine clearance less than 30 mL/min, severe liver impairment, or coadministered with diuretic |
|
Condition: Severe liver impairment |
Dose: Dose – Decrease dose Note: Decrease dose if creatinine clearance less than 30 mL/min, severe liver impairment, or coadministered with diuretic |
Administration
- Take with or without food
- Take at same time daily
Side Effect
- Peripheral edema (2-15%)
- Pulmonary edema (7-15%)
- Abdominal pain (1.6%)
- Dizziness (1.1-3.4%)
- Dyspepsia (1-2%)
- Fatigue (4.5%)
- Flushing (0.7-2.6%)
- Headache (7.3%)
- Male sexual dysfunction (1-2%)
- Muscle cramps (1-2%)
- Nausea (2.9%)
- Palpitation (0.7-4.5%)
- Rash (1-2%)
- Somnolence (1-2%)
- Weakness (1-2%)
- ARF of renal artery stenosis
- Cough (1-10%)
- Dizziness (4%)
- Fatigue (2%)
- Headache (6%)
- Nausea (1%)
- Postural dizziness (2%)
- serum creatinineeatinine increased (2%)
- Somnolence (2%)
- Analphylactoid reactions
- angioedema
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Catecholamine depleting drugs
|
Enhanced hypotension and bradycardia
|
|
Clonidine
|
Requires specific withdrawal timing to prevent rebound hypertension
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Angioedema
|
Risk of severe allergic reaction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.