Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult |
Dose: Enteric-coated tablet – 75-150 mg Frequency: two or three divided doses Note: A total of 75-150 mg daily. |
|
Age: Adult |
Dose: Sustained-release tablet (SR) – One tablet Frequency: once daily Note: Taken whole with liquid, preferably during a meal. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Juvenile rheumatoid arthritis |
Dose: Enteric-coated tablet – 1-3 mg/kg per day Frequency: in divided doses |
|
Indication: Juvenile rheumatoid arthritis |
Dose: Sustained-release tablet – Not recommended Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment |
Dose: Systemic – Lowest effective dose Duration: Shortest possible duration Note: Avoid if possible or use with caution. Avoid in severe impairment. In renal impairment monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure. |
|
Age: Adult Condition: Renal impairment |
Dose: Intravenous – Not specified Note: Avoid intravenous use if serum creatinine greater than 160 micromol/litre. Contraindicated in moderate or severe renal impairment. |
Administration
- Take with food
- Take after meals
Side Effect
- gastrointestinal discomfort
- epigastria pain
- eructation
- nausea and Diarrhoea
- headache and bleeding sometime may occur
- Occasionally skin rash
- peripheral oedema and abnormalities of serum transaminase have been reported
- Very rarely reported side effects include activation of peptic ulcer
- haematemesis or melena
- blood dyscrasia (extensive usage)
- There have been isolated reports of anaphylactoid reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Methotrexate
|
May increase serum levels
|
|
Other NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban) (e.g. warfarin)
|
Higher risk of GI bleeding
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Peptic Ulcer
|
Risk of bleeding
|
|
Asthma
|
Can trigger asthma attack
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.