Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Opioid Dependence Age: Adult Condition: Prevention of relapse after opioid detoxification |
Dose: by mouth – 25 mg initially Frequency: once daily Note: Observation for 1 hour after initial dose, then 50 mg once daily starting on day 2; used only after patient has been opioid-free for 7-10 days and after negative naloxone challenge; flexible dosing regimens can be employed to accommodate patient convenience or ensure compliance |
|
Indication: Opioid Dependence Age: Adult Condition: Maintenance of abstinence |
Dose: intramuscular – 380 mg Frequency: every 4 weeks Note: Administered in gluteal muscle; used only after patient has been opioid-free for 7-10 days and after negative naloxone challenge |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Form – Not established Note: Safety and efficacy not established |
Administration
- May be taken with or without food
- Take exactly as prescribed
Side Effect
- 69% includes bruising
- induration
- nodules
- pain
- pruritus
- swelling
- tenderness
- Nausea (33%)
- Headache (25%)
- Decreased appetite (14%)
- Insomnia (14%)
- Vomiting (14%)
- Diarrhea (13%)
- Dizziness (13%)
- Upper respiratory tract infection (URTI) (URTI) (13%)
- Anxiety (12%)
- Arthralgia (12%)
- Increased creatine phosphokinase (11%)
- Pharyngitis (11%)
- Depression (8%)
- Muscle cramps (8%)
- Back pain (6%)
- Rash (6%)
- Dry mouth (5%)
- Somnolence (4%)
- Increased aspartate aminotransferase (AST) (2%)
- Alopecia
- Dyspnea
- Edema
- Hepatocellular injury
- Increased systolic and diastolic blood pressures
- Liver function abnormalities
- Labored breathing
- Nonspecific electrocardiographic (ECG) changes
- drug craving
- confusion
- drowsiness
- visual hallucinations
- abdominal pain
- vomiting
- diarrhea)
- Palpitation
- Phlebitis
- Tachycardia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Opiate-containing preparations
|
May reduce effects
|
|
Drugs that alter hepatic metabolism
|
Increased or decreased serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Opioid Dependence
|
Risk of withdrawal
|
|
Acute Hepatitis
|
Can worsen liver condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.