Medicine Overview

Indication
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Adult Dose
Clinical InformationAdministration Information
Indication: Hypertension
Age: Adult
Dose: Conventional Tablet – Initially, 0.5 mg
Frequency: twice daily or three times daily
Duration: for 3-7 days
Note: thereafter increased to 1 mg twice daily or three times daily for the next 3-7 days; then daily dose increased gradually as determined by blood pressure response; maintenance dosage of Prazosin alone up to 15 mg daily in divided doses; Max: 20 mg/day in divided doses; dosage should be individualized depending on patient tolerance and response
Indication: Hypertension
Age: Adult
Dose: Extended Release Tablet – Initially, 2.5 mg
Frequency: once daily
Note: dosage may be increased slowly, in general over a 7 to 14 day period, depending on response; maintenance dose may be increased as clinically indicated to 20 mg given in once-daily doses; Max: doses above 20 mg once daily have not been studied; dosage should be individualized depending on patient tolerance and response; hypertensive patients controlled on Prazosin tablets may be switched to extended release at equivalent or nearest higher total daily dose (e.g. 4 mg tablets equivalent to 5 mg extended release once daily)

Child Dose
Clinical InformationAdministration Information
Age: Pediatric
Dose: No approved pediatric dosage available
Note: No approved pediatric dosage available

Renal Dose
Clinical InformationAdministration Information
Condition: Renal impairment
Dose: Not specified
Note: Dose reduction needed.
Administration
  • Can be taken with or without food
  • Initial dose best with dinner
Side Effect

Drug Interaction
Drug NameRisk Factors
Diuretics, Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
Hypotensive effects may be enhanced
Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol), Calcium Channel Blockers (Amlodipine, Diltiazem, Verapamil, Nifedipine, Felodipine, Nicardipine, Isradipine)
Increased risk of first dose hypotension

Disease Interaction
Disease NameRisk Factors
Congestive Heart Failure
Can worsen mechanical obstruction

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep away from light and moisture, store below 30° C. Keep away from reach out of the children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.