Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Benign gastric and duodenal ulceration and NSAID associated ulceration Age: Adult |
Dose: Tablet – 800 mcg Frequency: daily (in 2-4 divided doses) with breakfast or main meals and at bedtime Duration: at least 4 weeks and may be continued for up to 8 weeks if required |
|
Indication: Prophylaxis of NSAID induced gastric and duodenal ulcer |
Dose: Tablet – 200 mcg Frequency: 2-4 times daily taken with NSAID Note: If this dose cannot be tolerated, a dose of 100 mcg can be used. Misoprostol should be taken for the duration of NSAID therapy |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Use with caution; peak plasma concentration, half-life, and bioavailability may be increased, but it is not clear whether these increases are of clinical relevance |
Administration
- Take with food
- Take with plenty of water
Side Effect
- Diarrhea (14-40%)
- Abdominal pain (13-20%)
- Headache (2%)
- Anaphylaxis
- Anemia
- Cardiac dysrhythmia
- Chest pain
- Flatulence
- Gastrointestinal hemorrhage
- Hearing loss
- Myocardial infarction
- Nausea
- Rupture of uterus
- Thromboembolic disorder
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Oxytocin
|
May increase effects
|
|
Magnesium-containing antacids
|
Increased risk of misoprostol-induced diarrhoea
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Allergy to Prostaglandins
|
Risk of severe allergic reactions
|
|
Women of Childbearing Potential
|
Risk of pregnancy complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light and moisture. Keep out of the reach of the children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.