Medicine Overview

Indication
Know Medicine, Follow Guideline

Adult Dose
Clinical InformationAdministration Information
Indication: Susceptible infections
Age: Adult
Dose: Intravenous – 15,000-25,000 U/kg daily
Frequency: continuous intravenous drip or intermittent infusion every 12 hours at 60-120 minute duration
Note: Maximum: 2,000,000 U/day
Indication: Susceptible infections
Age: Adult
Dose: Intramuscular – 25,000-30,000 U/kg daily
Frequency: in divided doses every 4-6 hours
Note: Maximum: 2,000,000 U/day

Child Dose
Clinical InformationAdministration Information
Indication: Susceptible infections
Age: Adult
Dose: Intravenous – 15,000-25,000 U/kg
Frequency: daily
Note: by continuous intravenous drip or intermittent infusion every 12 hours at 60-120 min duration. Maximum: 2,000,000 U/day
Indication: Susceptible infections
Age: less than 2 years
Dose: Intravenous – 40,000 U/kg
Frequency: daily in divided doses every 12 hours

Renal Dose
Clinical InformationAdministration Information
Condition: Renal Impairment with Creatinine Clearance greater than 20 mL/minute
Dose: Usual dose – 75-100% usual dose/day
Frequency: divided every 12 hours
Condition: Renal Impairment with Creatinine Clearance 5-20 mL/minute
Dose: Usual dose – 50% usual dose/day
Frequency: divided every 12 hours
Administration
  • Can be given IV or IM
  • For IV, infuse over 60-90 minutes
Side Effect

Drug Interaction
Drug NameRisk Factors
Bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, colistin
Additive neurotoxic or nephrotoxic effect
Neuromuscular blockers (e.g. anesthetics, Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene))
Increased risk of respiratory paralysis

Disease Interaction
Disease NameRisk Factors
Nephrotoxic Drug Use
Increased kidney damage risk
Neurotoxic Drug Use
Risk of nerve damage

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Before reconstitution, do not store above 30°C; and keep away from light and out of the reach of children. After reconstitution or dilution, unused portion must be stored at 2° to 8°C and should be discarded after 72 hours if not used.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.