Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Deep vein thrombosis prophylaxis Condition: Knee replacement surgery |
Dose: Tablet by mouth – 10 mg Frequency: once daily Duration: 12 days Note: May take with or without food. Administer initial dose at least 6-10 hours after surgery once hemostasis has been established. |
|
Indication: Deep vein thrombosis prophylaxis Condition: Hip replacement surgery |
Dose: Tablet by mouth – 10 mg Frequency: once daily Duration: 35 days Note: May take with or without food. Administer initial dose at least 6-10 hours after surgery once hemostasis has been established. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Nonvalvular atrial fibrillation Condition: Creatinine Clearance 30–50 mL/minute |
Dose: Tablet – 20 mg Frequency: once daily |
|
Indication: Nonvalvular atrial fibrillation Condition: Creatinine Clearance 15–50 mL/minute |
Dose: Tablet – 15 mg Frequency: once daily |
Administration
- 10mg: Can be taken with or without food
- 15mg & 20mg: Take with food
Side Effect
- Abdominal pain (Less than 2%)
- Back pain (Less than 4%)
- Blister (1%)
- Bruising (3%)
- Constipation (Less than 3%)
- Diarrhea (Less than 5%)
- Dizziness (Less than 6%)
- Dyspepsia (Less than 2%)
- Epistaxis (4-10%)
- Fatigue (Less than 3%)
- Headache (3-5%)
- Nausea (1-3%)
- Hematuria (Less than 4%)
- Muscle spasm (1%)
- Oropharyngeal pain (Less than 1%)
- Osteoarthritis (Less than 2%)
- Peripheral edema (Less than 6%)
- Pruritus (Less than 2%)
- Pyrexia (1-3%)
- Rash (2%)
- Syncope (Less than 2%)
- Toothache (Less than 1%)
- Urinary Tract Infection (UTI) (Less than 1%)
- Vomiting (Less than 2%)
- Wound secretion (Less than 3%)
- Atrial fibrillation (21%, major bleeding 6%)
- DVT prophylaxis (5-6%, major bleedingLess than 1%)
- DVT treatment (6-10%, major bleeding 1%)
- Hematoma (Less than 3%)
- Agranulocytosis
- Hepatitis
- Dysuria
- Fatal bleeding
- Hematoma
- Hemiparesis
- Hemorrhage
- Hypotension
- Increased amylase
- Increased BUN
- Jaundice
- Menorrhagia
- Retroperitoneal bleeding
- Stevens-Johnson syndrome
- Thrombocytopenia
- Urticaria
- Xerostomia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Clarithromycin, Erythromycin, Fluconazole
|
Reduced hepatic & renal clearance
|
|
Ketoconazole, Itraconazole, Voriconazole, Posaconazole, Ritonavir
|
Increased bleeding risk
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Pathological Bleeding
|
Increases bleeding risk
|
|
Recent GI Ulcer
|
High risk of bleeding
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool (below 30°C) & dry place protected from light. Keep away from the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.