Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Malaria Acute treatment |
Dose: by mouth – 800 mg Frequency: then 400 mg by mouth 6-8 hours later, then 400 mg by mouth at 24 and 48 hours |
|
Indication: Prophylaxis |
Dose: by mouth – 400 mg Frequency: weekly Duration: starting 2 weeks before exposure and continued for 4 weeks after departure from area |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Malaria Condition: Acute treatment |
Dose: by mouth (oral) – 13 mg/kg base Frequency: initial dose, then 6.5 mg/kg base 6 hours later, then 6.5 mg/kg base at 24 and 48 hours Note: not to exceed 400 mg/day base |
|
Indication: Malaria Condition: Prophylaxis |
Dose: by mouth (oral) – 6.5 mg/kg base Frequency: weekly Duration: starting 2 weeks before exposure and continued for 4 weeks after departure from area Note: not to exceed 400 mg (310 mg base) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Adjusted accordingly Note: Estimation of plasma hydroxychloroquine levels to be undertaken in patients with severely compromised function and dosage adjusted accordingly |
Administration
- Take with food
- Regular timing
Side Effect
- Retinopathy
- hair loss
- photosensitivity
- tinnitus
- myopathy (long-term therapy)
- Psychosis
- seizures
- leucopenia and rarely aplastic anaemia
- hepatitis
- GI upsets
- dizziness
- hypokalaemia
- headache
- pruritus
- urticaria
- difficulty in visual accommodation
- Loss of hair
- bleaching of hair pigment
- bluish-black pigmentation of the mucous membranes and skin
- photosensitivity
- tinnitus
- reduced hearing
- nerve deafness
- neuromyopathy
- and myopathy
- including cardiomyopathy
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cimetidine
|
May increase serum levels of hydroxychloroquine
|
|
Kaolin, Mg trisilicate
|
May decrease absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Retinal Or Visual Field Changes
|
Can cause permanent eye damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.