Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is a tyrosine kinase inhibitor. It slows down the fibrosis process. It's used to treat idiopathic pulmonary fibrosis.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Take with food • Swallow capsules whole • Do not chew or crush • Take at same time each day

Question 3

When should this medicine not be used?

Accepted Answer

• In severe liver disease • During pregnancy • In bleeding risk • In active peptic ulcer

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• May cause liver problems - regular tests needed • May cause diarrhea - stay hydrated • May increase risk of bleeding • Not recommended during pregnancy

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Can cause fetal harm • Avoid use during pregnancy • Use effective contraception during treatment and for at least 3 months after

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• May cause liver problems - regular tests needed • May cause diarrhea - stay hydrated • May increase risk of bleeding • Not recommended during pregnancy

Question 7

Is this medicine suitable for children and elderly?

Accepted Answer

• Not established in children 0-18 years. • No dose adjustment needed for elderly, but patients over 75 may need dose reduction.

Question 8

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For twice-daily dosing: If more than 6 hours until your next dose, take the missed dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 9

What should be done in case of an overdose?

Accepted Answer

• Symptoms: Diarrhea, elevated liver enzymes. • Treatment: Fluid replacement, monitor liver function.

Question 10

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Diarrhea, nausea, abdominal pain, liver problems, decreased appetite, vomiting • What to do: Take with food; Stay hydrated; Regular liver tests; Report severe diarrhea; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 11

What is Nifev 100 100mg used for?

Accepted Answer

Nifev 100 100mg (Nintedanib) is a pharmaceutical medicine manufactured by UniMed UniHealth Pharmaceuticals Ltd. in Bangladesh. It is primarily prescribed for Chronic Fibrosing Interstitial Lung Diseases, Idiopathic Pulmonary Fibrosis (IPF), Locally Recurrent Non-Small Cell Lung Cancer (NSCLC), Locally-Advanced Non-Small Cell Lung Cancer (NSCLC), Metastatic Non-Small Cell Lung Cancer (NSCLC), Systemic Sclerosis associated Interstitial Lung Disease.

Question 12

What is the active generic component of Nifev 100?

Accepted Answer

The active ingredient in Nifev 100 is Nintedanib, belonging to the Tyrosine Protein Kinase Inhibitors drug class.

Question 13

What is the retail price of Nifev 100 100mg in Bangladesh?

Accepted Answer

The official retail price of Nifev 100 100mg (Capsule) is ৳250.00 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 14

What is the recommended dosage for Nifev 100?

Accepted Answer

Standard adult dosage: Oral – 150 mg (twice daily). Pediatric dosage: Oral – 50 mg (Twice daily). Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 15

Is Nifev 100 safe during pregnancy and breastfeeding?

Accepted Answer

Nifev 100 is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 16

What are the common side effects of Nifev 100?

Accepted Answer

**More than 10%**; **Idiopathic pulmonary fibrosis**; Diarrhea (62%);Nausea (24%);Abdominal pain (15%);Elevated liver enzymes (14%);Vomiting (12%);Decreased appetite (11%); **SSc-ILD**; Diarrhea (76%);Nausea (32%);Vomiti

Clinical Information	Administration Information
Indication: Idiopathic Pulmonary Fibrosis, Chronic Fibrosing Interstitial Lung Diseases with a Progressive Phenotype, Systemic Sclerosis-associated Interstitial Lung Disease Age: Adult	Dose: Oral – 150 mg Frequency: twice daily Note: Maximum: 300 mg daily
Indication: Locally advanced non-small cell lung carcinoma, Locally recurrent non-small cell lung carcinoma, Metastatic non-small cell lung carcinoma Age: Adult Condition: In combination with docetaxel	Dose: Oral – 200 mg Frequency: twice daily on days 2 to 21 of a 21-day treatment cycle Note: Maximum: 400 mg daily

Clinical Information	Administration Information
Indication: Clinically significant, progressive fibrosing interstitial lung diseases and systemic sclerosis-associated interstitial lung disease Age: 6 to 17 years	Dose: Oral – 50 mg Frequency: Twice daily Note: Route: Oral
Indication: Clinically significant, progressive fibrosing interstitial lung diseases and systemic sclerosis-associated interstitial lung disease Age: 6 to 17 years	Dose: Oral – 75 mg Frequency: Twice daily Note: Route: Oral

Clinical Information	Administration Information
Condition: Mild-to-moderate renal impairment	Dose: Not specified Note: No dosage adjustment required
Condition: Severe renal impairment (Creatinine Clearance less than 30 mL/min) or End Stage Renal Disease	Dose: Not specified Note: Not studied

Drug Name	Risk Factors
Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)	Increased risk of gastrointestinal adverse effect
Strong P-gp inhibitors (e.g. ketoconazole, erythromycin, ciclosporine)	Increased plasma concentration

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

Is this medicine suitable for children and elderly?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources