Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Locally advanced or metastatic non-small cell lung carcinoma Age: Adult |
Dose: Oral – 150 mg Frequency: once daily Note: Until disease progression or unacceptable toxicity. Reduce dose in decrements of 50 mg when necessary. |
|
Indication: Locally advanced, unresectable or metastatic pancreatic cancer Age: Adult Condition: As 1st-line treatment with gemcitabine |
Dose: Oral – 100 mg Frequency: once daily Note: Reduce dose in decrements of 50 mg when necessary. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not recommended |
Administration
- Take on empty stomach
- Take 1 hour before or 2 hours after meals
Side Effect
- Rash (75-76%)
- Anorexia (52-69%)
- Diarrhea (54-55%)
- Fatigue (52-79%)
- Nausea (33-40%)
- Infection (39%)
- Vomiting (23-25%)
- Dyspnea (24%)
- Stomatitis (17-19%)
- Cough (16%)
- Pruritus (13%)
- Conjunctivitis (12%)
- Dry skin (12%)
- Keratoconjunctivitis sicca (12%)
- Abdominal pain (11%)
- Elevated LFT's (grade 2)
- Acne
- Paronychia
- Weight loss
- Pneumonitis pulmonary infiltrate
- Pulmonary fibrosis
- Interstitial lung disease-like events
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, atazanavir)
|
Increased serum levels
|
|
CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital)
|
May reduce exposure of erlotinib
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at a temperature not exceeding 30°C in a dry place. Protect from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.