Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: Adult
Dose: Oral – 150 mg
Frequency: once daily
Note: May increase to 300 mg once daily if needed.
Indication: Hypertension
Age: Adult
Condition: Intravascular volume depletion
Dose: Oral – 75 mg
Frequency: once daily
Note: Initial dose.

Child Dose

Clinical InformationAdministration Information
Indication: Hypertension
Age: less than 6 years
Dose: Safety and efficacy not established
Note: Safety and efficacy not established
Indication: Hypertension
Age: 6-12 years
Dose: Oral – 75 mg/day
Note: by mouth (oral)

Renal Dose

Clinical InformationAdministration Information
Condition: Haemodialysis
Dose: Not specified – 75 mg
Frequency: once daily
Condition: Mild-to-severe renal impairment
Dose: Not specified – Dosage adjustment not necessary
Note: unless patient is hypovolemic
Administration
  • Can take with/without food
  • Regular timing
Side Effect

Drug Interaction

Drug NameRisk Factors
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
May antagonise hypotensive effect and increase risk of nephrotoxicity
Lithium
May increase serum lithium levels and toxicity

Disease Interaction

Disease NameRisk Factors
High Blood Pressure, Heart Disease
May cause dangerous drop in blood pressure and kidney problems

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.