Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – Initially 2 mg, may increase to 4 mg Frequency: once daily Duration: may increase after 3-4 weeks Note: Maximum dose: 6 mg/day. |
|
Indication: Hypertension Age: Adult Condition: Severe hepatic impairment |
Dose: Oral Note: Reduce dose. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Headache
- flushing
- oedema
- dizziness
- palpitations
- aggravation of angina
- increased alkaline phosphatase
- Rarely asthenia
- rash (eg erythema and itching)
- gastric upset
- nausea
- gum hyperplasia
- polyuria
- muscle cramps
- mood disturbances
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene), ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol)
|
Additive effect
|
|
Cimetidine
|
May increase plasma level
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Within 1 month of MI
|
Risk of cardiac complications
|
|
Cardiogenic shock
|
Can worsen shock state
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protect from light and moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.