Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Partial-onset seizures Age: Adult |
Dose: Oral – Initially 2 mg Frequency: once daily at bedtime Note: May be increased by increments of 2 mg (either weekly or every 2 weeks) to a maintenance dose of 4-8 mg daily, with 1 week interval between dose increases. Maximum dose: 12 mg daily. |
|
Indication: Primary generalised tonic-clonic seizures Age: Adult |
Dose: Oral – Initially 2 mg Frequency: once daily at bedtime Note: May be increased by increments of 2 mg (either weekly or every 2 weeks) to a maintenance dose of 8 mg daily, with 1 week interval between dose increases. Then, may be further increased up to 12 mg daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Partial Onset Seizures Age: less than 4 years |
Dose: Safety and efficacy not established |
|
Indication: Partial Onset Seizures Age: greater than 4 years Condition: Initial (In absence of enzyme-inducing antiepileptic drugs) |
Dose: Dose – 2 mg Frequency: once daily at bedtime Note: increase by 2 mg/day increments in at least weekly intervals to 4-8 mg daily at bedtime based on clinical response and tolerability |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Moderate renal impairment |
Dose: Not specified Note: May be used with close monitoring and slower titration |
|
Condition: Severe renal impairment or hemodialysis |
Dose: Not specified Note: Not recommended |
Administration
- May be taken with or without food
- Take at bedtime
Side Effect
- Dizziness (16-43%)
- Somnolence (9-18%)
- Headache (11-13%)
- Fatigue (8-12%)
- Irritability (4-12%)
- Falls (2-10%)
- Nausea (6-8%)
- Ataxia (1-8%)
- Vertigo (3-5%)
- Balance disorder (3-5%)
- Back pain (2-5%)
- Weight gain (4%)
- Vomiting (2-4%)
- Anxiety (3-4%)
- Blurred vision (1-4%)
- Dysarthria (1-4%)
- Cough (1-4%)
- Hypoaesthesia (3%)
- Constipation (2-3%)
- Arthralgia (2-3%)
- Extremity pain (2-3%)
- Aggression (1-3%)
- Anger (1-3%)
- Myalgia (1-3%)
- Diplopia (1-3%)
- Injuries due to falls (1-3%)
- Hypersomnia (1-3%)
- Hyponatremia (2%)
- Contusions (2%)
- Oropharyngeal pain (2%)
- Asthenia (1-2%)
- Confusional state (1-2%)
- Euphoric mood (1-2%)
- Altered mood (1-2%)
- Abnormal coordination (1-2%)
- Musculoskeletal pain (1-2%)
- Peripheral edema (1-2%)
- Memory impairment (1-2%)
- Paraesthesia (1-2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Levonorgestrel
|
Decreased exposure
|
|
Progestative containing OCs
|
May decrease efficacy
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Protect from light and moisture, store below 30°C. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.