Medicine Overview

Indication

Know Medicine, Follow Guideline

Adult Dose

Clinical InformationAdministration Information
Indication: Hypertension
Dose: Tablet – 50 mg/12.5 mg
Frequency: by mouth once daily
Note: Initial dose
Indication: Hypertension
Condition: Dose titrated upward
Dose: Tablet – 100 mg/25 mg
Frequency: by mouth once daily
Note: Do not exceed this final titration

Child Dose

Clinical InformationAdministration Information
Age: Pediatric
Dose: Not specified – Not specified
Note: Safety and efficacy not established

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment Creatinine Clearance less than 30 mL/minute
Dose: Thiazide-containing products – Do not use
Note: Loop diuretic preferred
Condition: Renal impairment Creatinine Clearance greater than 30 mL/minute
Dose: No dosage adjustment required
Note: No dosage adjustment required
Administration
  • Take at same time daily
  • Can take with/without food
Side Effect

Drug Interaction

Drug NameRisk Factors
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac) including selective COX-2 inhibitors
Reduced excretion of lithium; effect of diuretic, natriuretic & other antihypertensive
Aliskiren
Do not co-administer in patients with diabetes & renal impairment

Disease Interaction

Disease NameRisk Factors
Intravascular Volume Depletion
Can worsen dehydration

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep out of the reach of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.