Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension |
Dose: Tablet – 50 mg/12.5 mg Frequency: by mouth once daily Note: Initial dose |
|
Indication: Hypertension Condition: Dose titrated upward |
Dose: Tablet – 100 mg/25 mg Frequency: by mouth once daily Note: Do not exceed this final titration |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Not specified – Not specified Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Creatinine Clearance less than 30 mL/minute |
Dose: Thiazide-containing products – Do not use Note: Loop diuretic preferred |
|
Condition: Renal impairment Creatinine Clearance greater than 30 mL/minute |
Dose: No dosage adjustment required Note: No dosage adjustment required |
Administration
- Take at same time daily
- Can take with/without food
Side Effect
- Fatigue (14%)
- Hypoglycemia (14%)
- Chest pain (12%)
- Cough
- incidence higher in previous cough related to ACE therapy (3-11%)
- Diarrhea (2-10%)
- URI (8%)
- Hypotension (7%)
- Dizziness (4%)
- Nausea (2%)
- Hypotension
- Anorexia
- Epigastric distress
- Hypokalemia
- Phototoxicity
- Thrombocytopenia
- Hypersensitivity reactions
- hemolytic anaemia
- toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac) including selective COX-2 inhibitors
|
Reduced excretion of lithium; effect of diuretic, natriuretic & other antihypertensive
|
|
Aliskiren
|
Do not co-administer in patients with diabetes & renal impairment
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Intravascular Volume Depletion
|
Can worsen dehydration
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.