Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Postoperative Nausea and Vomiting Prevention |
Dose: Intravenous dose – 5 mg Frequency: single dose Note: Infused over 1 to 2 minutes at the time of induction of anesthesia |
|
Indication: Treatment of Postoperative Nausea and Vomiting Age: Adult Condition: Received antiemetic prophylaxis with an agent of a different class or have not received prophylaxis |
Dose: Intravenous dose – 10 mg Frequency: single dose Note: Infused over 1 to 2 minutes in the event of nausea and/or vomiting after a surgical procedure |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: less than 18 years |
Dose: Dose: Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild to severe renal impairment |
Dose: Intravenous – 5 mg or 10 mg Frequency: Single dose Note: No dosage adjustment is necessary. Pharmacokinetics changes following a single dose are not considered to be clinically meaningful. |
Administration
- Must be administered by healthcare professional
- Given as IV injection over 1-2 minutes
Side Effect
- Prevention of PONV
- Increased blood prolactin (5%)
- Chills (4%)
- Hypokalemia (4%)
- Procedural hypotension (3%)
- Abdominal distension (2%)
- Treatment of PONV
- Infusion site pain (6%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Drugs prolonging the QT interval
|
Avoid use; increased risk of QT prolongation
|
|
Dopamine Agonists (Bromocriptine, Pergolide, Ropinirole, Pramipexole) (e.g. levodopa)
|
Reciprocal antagonism of effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.