Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ocular hypertension Age: Adult |
Dose: Ophthalmic – 1 drop Frequency: twice daily Note: Instill to the affected eye. |
|
Indication: Open-angle glaucoma Age: Adult |
Dose: Ophthalmic – 1 drop Frequency: twice daily Note: Instill to the affected eye. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ocular hypertension; Open-angle glaucoma Age: less than 2 years |
Dose: Ophthalmic – 1 drop Note: Contraindicated |
|
Indication: Ocular hypertension; Open-angle glaucoma Age: greater than 2 years |
Dose: Ophthalmic – 1 drop Frequency: twice daily Note: Instill to the affected eye. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance (ml/min) less than 30 |
Dose: Dose: Note: Not recommended. |
Administration
- Clean eyes before use
- One drop in affected eye(s)
Side Effect
- Ocular burning
- stinging
- discomfort (33%)
- Bitter taste (25%)
- Superficial punctate keratitis (10-15%)
- Ocular allergic reactions (10%)
- Dorzolamide
- Blurred vision
- Ocular dryness
- Photophobia
- Ocular redness
- Tearing
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Arrythmia
- Bradycardia
- Syncope
- Fatigue
- Headache
- Dyspnea
- Bronchospasm
- Chest pain
- Edema
- Paresthesia
- Nausea
- Rales
- Depression
- Decreased exercise tolerance
- Raynaud's phenomenon
- Cardiac failure
- bronchospasm
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Oral Calcium Channel Blockers (Amlodipine, Diltiazem, Verapamil, Nifedipine, Felodipine, Nicardipine, Isradipine), Catecholamine-depleting Drugs (specific agents that deplete catecholamines), Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol), Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide) (e.g. amiodarone), Digitalis glycosides, Parasympathomimetics (Pilocarpine, Carbachol) (Ephedrine, Pseudoephedrine, Phenylephrine), Narcotics, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide)
|
Additive hypotension and bradycardia
|
|
Oral carbonic anhydrase or Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol)
|
Additive systemic side effects; avoid concurrent use
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Bronchial Asthma
|
Can trigger asthma attack
|
|
Severe COPD
|
Can worsen breathing
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30°C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.