Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is a polymyxin class antibiotic. It works by destroying the cell walls of bacteria. It is used to treat multi-drug resistant gram-negative bacterial infections.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Must be reconstituted before use • For IV or IM use only • Careful monitoring required

Question 3

When should this medicine not be used?

Accepted Answer

• Do not use if you have severe kidney disease • Do not use if you have myasthenia gravis • Do not use if you have porphyria

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Use carefully in patients with kidney problems • Adjust dose for patients with severe kidney issues • Use with caution in newborns, infants, and children

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Not safe during pregnancy; • Potential risks to fetus; • Use only if clearly needed

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Use carefully in patients with kidney problems • Adjust dose for patients with severe kidney issues • Use with caution in newborns, infants, and children

Question 7

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For thrice-daily dosing: If more than 3 hours until your next dose, take the missed dose. • For twice-daily dosing: If more than 6 hours until your next dose, take the missed dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 8

What should be done in case of an overdose?

Accepted Answer

• Overdose symptoms: Neuromuscular blockade, respiratory distress. • Treatment: Respiratory support, monitor renal function.

Question 9

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Dizziness, nerve problems, kidney issues, breathing difficulties • What to do: Regular kidney tests; Report breathing problems; Monitor urine output; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 10

What is Colistimethate 4.5 MIU (150mg) used for?

Accepted Answer

Colistimethate 4.5 MIU (150mg) (Colistin (Colistimethate Sodium)) is a pharmaceutical medicine manufactured by ZAS Corporation in Bangladesh. It is primarily prescribed for Bowel Sterilization, Gastrointestinal Tract Infections, Respiratory Tract Infections.

Question 11

What is the active generic component of Colistimethate?

Accepted Answer

The active ingredient in Colistimethate is Colistin (Colistimethate Sodium), belonging to the Miscellaneous Antibiotics drug class.

Question 12

What is the retail price of Colistimethate 4.5 MIU (150mg) in Bangladesh?

Accepted Answer

The official retail price of Colistimethate 4.5 MIU (150mg) (Injection) is ৳2750.00 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 13

What is the recommended dosage for Colistimethate?

Accepted Answer

Standard adult dosage: Oral – 1.5-3 million international units (three times daily). Pediatric dosage: Oral – dosage expressed in terms of colistin base. Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 14

Is Colistimethate safe during pregnancy and breastfeeding?

Accepted Answer

Colistimethate is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 15

What are the common side effects of Colistimethate?

Accepted Answer

**1-10%**; Dizziness;Paresthesia; tingling sensation; **Less than 1%**; Neurotoxicity;Nephrotoxicity;Acute respiratory failure (inhalation route);Respiratory tract paralysis; **Potentially Fatal**; Acute tubular necrosis

Clinical Information	Administration Information
Indication: Bowel sterilisation; Gastrointestinal infections Age: Adult	Dose: Oral – 1.5-3 million international units Frequency: three times daily Note: As colistin sulfate
Indication: Bowel sterilisation; Gastrointestinal infections Age: Child	Dose: Oral – 0.75-1.5 million international units Frequency: three times daily Note: As colistin sulfate

Clinical Information	Administration Information
Indication: Oral Susceptible Infections Age: less than 12 years old	Dose: Oral – dosage expressed in terms of colistin base Note: Safety and efficacy not established
Indication: Bowel sterilisation; Gastrointestinal infections Age: Child	Dose: Oral (as colistin sulfate) Note: Not suitable

Clinical Information	Administration Information
Condition: Renal Impairment with Creatinine Clearance greater than 80 mL/minute	Dose: Intravenous or Intramuscular – No dosage adjustment required Note: Renal Impairment CrCl greater than 80 mL/min: No dosage adjustment required
Condition: Renal Impairment with Creatinine Clearance 50-79 mL/minute	Dose: Intravenous or Intramuscular – 2.5-3.8 mg/kg/day Frequency: divided every 12 hours Note: Renal Impairment CrCl 50-79 mL/min: 2.5-3.8 mg/kg/day intravenous/intramuscular divided every 12 hours

Drug Name	Risk Factors
Chloramphenicol, trimethoprim	Potentiates
Curariform Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene)	Potentially Fatal: Potentiates action

Disease Name	Risk Factors
Anuria	Risk of drug toxicity
Porphyria	Risk of acute attacks

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources