Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Analgesia during induction of anesthesia
Age: Adult
Dose: Intravenous – Infuse at 0.5-1 mcg/kg/minute
Note: To be used in conjunction with an hypnotic agent (e.g. propofol, thiopentone, isoflurane). If the patient is to be intubated less than 8 minutes after the start of the infusion, an additional initial intravenous bolus of 1 mcg/kg may be given over 30-60 seconds.
Indication: Analgesia during maintenance of anesthesia
Age: Adult
Condition: Ventilated patients
Dose: Intravenous – 0.05-2 mcg/kg/minute
Note: Usual infusion doses range depending on the anesthetic drug used and titrated according to patient response. In response to light anesthesia or intense surgical stress, supplemental intravenous boluses of 0.5-1 mcg/kg may be administered every 2-5 minutes.

Child Dose

Clinical InformationAdministration Information
Indication: Intravenous Analgesia during maintenance of anaesthesia in ventilated patients
Age: Neonates
Dose: Intravenous infusion – 0.4-1.0 mcg/kg/minute
Note: depending on the anaesthetic method and adjust according to patient response, supplemental intravenous injection of 1 mcg/kg dose may be given
Indication: Intravenous Analgesia during maintenance of anaesthesia in ventilated patients
Age: 1-12 yr
Dose: Intravenous injection – initially 0.1-1 mcg/kg
Note: over at least 30 seconds (excluded if not needed)
Administration
  • For IV use only
  • Must be diluted before administration
Side Effect

Drug Interaction

Drug NameRisk Factors
Inhaled and IV anesthetics, Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam)
Increased CNS depression
Cardiac depressants (e.g. β-blockers, Calcium Channel Blockers (Amlodipine, Diltiazem, Verapamil, Nifedipine, Felodipine, Nicardipine, Isradipine))
Increased hypotension and bradycardia

Disease Interaction

Disease NameRisk Factors
Epidural/Intrathecal Administration
Risk of glycine toxicity
Sole Anesthesia Agent
Insufficient for complete anesthesia

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage

Details coming soon

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.