Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Major Depressive Disorder (MDD); Depressive phase of bipolar disorder Age: Adult |
Dose: Oral – 20 mg Frequency: once daily Note: Initial dosage; after one week may increase to maximum dosage of 40 mg once daily |
|
Indication: Panic disorder with or without agoraphobia Age: Adult |
Dose: Oral – 10 mg Frequency: once daily Duration: 1 week Note: Initial dosage |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Not applicable – Contraindicated Note: Contraindicated. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose: Note: No dosage adjustment needed. |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Dry mouth (20%)
- Nausea (21%)
- Somnolence (18%)
- Insomnia (15%)
- Xerostomia (20%)
- Increased sweating (11%)
- Tremor (8%)
- Diarrhea (8%)
- Ejaculation disorder (6%)
- Rhinitis (5%)
- Upper respiratory infection (5%)
- Dyspepsia (5%)
- Fatigue (5%)
- Vomiting (4%)
- Anxiety (4%)
- Anorexia (4%)
- Abdominal pain (3%)
- Agitation (3%)
- Impotence (3%)
- Sinusitis (3%)
- Dysmenorrhea (3%)
- Decreased libido (2%)
- Yawning (2%)
- Arthralgia (2%)
- Myalgia (2%)
- Amenorrhea (More than 1%)
- Confusion (More than 1%)
- Cough (More than 1%)
- Flatulence (More than 1%)
- Increased saliva (More than 1%)
- Migraine (More than 1%)
- Orthostatic hypotension (More than 1%)
- Paresthesia (More than 1%)
- Polyuria (More than 1%)
- Pruritus (More than 1%)
- Rash (More than 1%)
- Tachycardia (More than 1%)
- Weight change (More than 1%)
- Increased risk of suicidal thinking and behaviour especially in child and adolescents
- Monitor closely for signs of clinical worsening
- suicidality or unusual changes in behaviour
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Warfarin
|
May increase anticoagulant effect
|
|
Sibutramine
|
Increased risk of hypomania
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Treatment Of Depressive Illness
|
Not for standalone use in severe depression
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.