Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension |
Dose: Oral – 5 mg/20 mg Frequency: once daily Note: Initially; may increase the dose after 1-2 weeks; not to exceed 10 mg/40 mg. May be administered concomitantly with other antihypertensive agents. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not mentioned Note: Avoid use in severe renal impairment (Creatinine Clearance less than 20 mL/minute) |
Administration
- Take with or without food
- Take once daily
Side Effect
- Peripheral edema (11%)
- Palpitation
- Nocturia
- Urinary frequency
- Orthostatic hypotension
- Pruritus
- Rash
- Acute renal failure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Potassium-sparing diuretics (Amiloride, Eplerenone, Spironolactone, Triamterene), K salts, K supplements
|
Increased risk of hyperkalaemia
|
|
Other Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
|
May potentiate BP lowering effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Biliary Obstruction
|
Risk of complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.