Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Rheumatic disorders Age: Adult |
Dose: Oral – 100-200 mg/day Frequency: in 2-4 divided doses Note: Maximum: 300 mg/day in divided doses. As modified-release formulation: Administer dose once daily. |
|
Indication: Pain and inflammation Age: Adult |
Dose: Oral – 25-50 mg Frequency: every 6-8 hours Note: Maximum: 300 mg/day in divided doses. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Mild |
Dose: Maximum: 150 mg/day Note: Maximum: 150 mg/day; |
|
Condition: Renal impairment Severe |
Dose: Maximum: 100 mg/day Note: Maximum: 100 mg/day |
Administration
- Take with food
- Take with full glass of water
Side Effect
- Increased liver function test (up to 15%)
- Dizziness (3-9%)
- Headache (3-9%)
- Impaired renal function disorder (3-9%)
- Upper GI ulcers
- Nausea (More than 3%)
- Diarrhea (More than 3%)
- Abdominal pain (More than 3%)
- Constipation (More than 3%)
- Flatulence (More than 3%)
- Rash (1-3%)
- Stomatitis (1-3%)
- Insomnia (1-3%)
- Malaise (1-3%)
- Depression (1-3%)
- Ketoprofen-induced peptic ulcer
- GI bleeding (More than 2% in long-term studies)
- Peripheral edema (2%)
- Bronchospasm (Less than 2%)
- Myocardial infarction (Less than 2%)
- Congestive heart failure (Less than 1%)
- Hypertension (Less than 1%)
- Scaling eczema
- Stevens-Johnson syndrome (Less than 0.1%)
- Gastrointestinal hemorrhage (Less than 1%)
- Gastrointestinal perforation (Less than 1%)
- Melena (Less than 1%)
- Agranulocytosis (Less than 1%)
- Anemia (Less than 1%)
- Thrombocytopenia (Less than 1%)
- Hepatitis (Less than 1%)
- Anaphylactoid reaction (Less than 1%)
- Immune hypersensitivity reaction
- Cerebrovascular accident
- Interstitial nephritis (Less than 1%)
- Renal failure (Less than 1%)
- Anaphylaxis
- exfoliative dermatitis
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Lithium, methotrexate
|
Increases plasma concentrations
|
|
Antihypertensives (e.g. ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), angiotensin II receptor antagonists)
|
Reduces effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active GI bleeding/ulcer
|
Risk of serious bleeding
|
|
Severe heart failure
|
Can worsen heart condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Protect from light. Store below 30°C. Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.