Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis C Age: Adults and Adolescents Condition: Genotypes 1-6, without cirrhosis |
Dose: Tablet – 3 tablets (300 mg/120 mg total dose) Frequency: once daily Duration: 8 weeks Note: Take by mouth with food. |
|
Indication: Chronic Hepatitis C Age: Adults and Adolescents Condition: Genotypes 1-6, compensated cirrhosis (Child-Pugh A) |
Dose: Tablet – 3 tablets (300 mg/120 mg total dose) Frequency: once daily Duration: 12 weeks Note: Take by mouth with food. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute or chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6 infection Age: 3 years and older |
Dose: Packets – 150 mg/60 mg (three 50 mg/20 mg packets) Frequency: once daily Note: by mouth (oral); Maximum Dose: 300 mg glecaprevir and 120 mg pibrentasvir daily |
|
Indication: Acute or chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6 infection Age: 3 years and older |
Dose: Packets – 200 mg/80 mg (four 50 mg/20 mg packets) Frequency: once daily Note: by mouth (oral); Maximum Dose: 300 mg glecaprevir and 120 mg pibrentasvir daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Mild, moderate, or severe, including patients on dialysis |
Dose: Not mentioned Note: No dosage adjustment required |
Administration
- Take with food
- Take at same time daily
Side Effect
- Headache (9-17%)
- Fatigue (11-14%)
- Nausea (6-12%)
- Diarrhea (3-7%)
- Increased bilirubin, ≥2x ULN (3.5%)
- Pruritus (7%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampin, atazanavir
|
Contraindicated
|
|
Carbamazepine, efavirenz, St John's wort
|
Not recommended
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Impairment
|
Risk of drug toxicity in severe liver disease (Child-Pugh C)
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at or below 30°C
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.