Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Sedation Age: Adult |
Dose: Oral – 30-120 mg Frequency: daily in 2-3 divided doses Note: do not exceed 400 mg/day |
|
Indication: Status epilepticus; Emergency management of acute seizures Age: Adult |
Dose: Oral – 100-300 mg Frequency: daily at bedtime |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Sedation Age: Child |
Dose: Oral – 2 mg/kg Frequency: daily in 3 divided doses |
|
Indication: Status epilepticus ; Emergency management of acute seizures Age: Child |
Dose: – 3-5 mg/kg or 125 mg/m2 Frequency: daily |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not mentioned Note: Reduce dose. Severe: Contraindicated. |
Administration
- May be taken with or without food
- Take at same time daily
Side Effect
- Ataxia
- Dizziness
- Drowsiness
- Dysarthria
- Fatigue
- Headache
- Irritability
- Nystagmus
- Paresthesia restlessness
- Vertigo Geriatric patients Excitement
- confusion
- depression
- Pediatric patients Paradoxical excitement/hyperactivity
- Mental dullness
- Constipation
- Diarrhea
- Nausea
- Vomiting
- Megaloblastic (folate-deficiency) anemia
- Rash
- Hypocalcemia
- Hepatotoxicity
- Stevens-Johnson syndrome
- Rickets
- Osteomalacia
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Paracetamol
|
May enhance hepatotoxic potential of overdoses
|
|
Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole)
|
Decreased levels through enzyme induction
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Disorders
|
Risk of drug accumulation
|
|
Severe Hepatic Disorders
|
Impaired drug metabolism
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.