Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV-1 Infection Condition: less than 3 lopinavir resistance-associated substitutions |
Dose: Tablet – 400 mg/100 mg Frequency: every 12 hours Note: Taken by mouth. |
|
Indication: HIV-1 Infection Condition: less than 3 lopinavir resistance-associated substitutions |
Dose: Tablet – 800 mg/200 mg Frequency: once daily Note: Taken by mouth. Once-daily dosing is only recommended for protease inhibitor-naive patients and not for pregnant women or coadministration with efavirenz, nevirapine, fosamprenavir, nelfinavir, carbamazepine, phenytoin, or phenobarbital. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: HIV-1 Infection Age: less than 2 weeks |
Dose: Not applicable – Safety and efficacy not established Note: Do not use once-daily dosing in children or adolescents (administer every 12 hours) |
|
Indication: HIV-1 Infection Age: 2 weeks to 6 months |
Dose: Oral solution – 300 mg/75 mg (lopinavir/ritonavir) per m² Frequency: twice daily Note: by mouth (oral); Use of 300 mg/75 mg (lopinavir/ritonavir) per m² in infants aged less than 6 months associated with lower lopinavir trough levels than those found in adults; evaluate lopinavir dosing and adjusted for growth at frequent intervals; Do not administer with efavirenz, nevirapine, fosamprenavir, or nelfinavir in infants aged less than 6 months |
Administration
- Tablets: can take with or without food
- Capsules/solution: take with food
Side Effect
- Diarrhea (7-9%)
- Hyperlipidemia (3-39%)
- Nausea (5-16%)
- Rash (12%)
- Abdominal pain (1-11%)
- Nausea (5-16%)
- ALT increased (1-11%)
- Headache (2-6%)
- Elevated LFTs (2-10%)
- Weakness (Less than 9%)
- Hyperuricemia (Less than 5%)
- Flatulence (1-4%)
- Neutropenia (1-5%)
- Stevens Johnson Syndrome
- Erythema multiforme
- Toxic epidermal necrolysis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenobarbital, Carbamazepine, Dexamethasone, Phenytoin, Rifabutin, Rifampicin
|
Decreased plasma concentration of Ritonavir + Lopinavir
|
|
Sildenafil
|
May increase serum levels of sildenafil
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Severe allergic reactions may occur
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a dry place & store below 30° C. Protect from light & keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.