Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute attack of Chloroquine resistant falciparum malaria Age: Adult |
Dose: Oral Tablet – 2-3 tablets (per tablet contains pyrimethamine 25 mg and sulfadoxine 500 mg) Frequency: single dose Note: Do not repeat for at least 7 days. Hepatic impairment: Dose reduction may be needed. Severe hepatic impairment: contra-indicated. |
|
Indication: Malaria Prophylaxis Age: Adult |
Dose: Oral Tablet – 1 tablet Frequency: once weekly Note: Hepatic impairment: Dose reduction may be needed. Severe hepatic impairment: contra-indicated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chloroquine resistant falciparum malaria acute attack Age: Child Condition: less than 2 years |
Dose: Tablet – ½ tablet Frequency: single dose Note: Do not repeat for at least 7 days |
|
Indication: Chloroquine resistant falciparum malaria acute attack Age: Child Condition: 2-5 years |
Dose: Tablet – 1 tablet Frequency: single dose Note: Do not repeat for at least 7 days |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not mentioned – Not mentioned Note: Dose reduction may be needed |
|
Condition: Severe renal impairment |
Dose: Not mentioned – Not mentioned Note: Contra-indicated |
Administration
- Take with plenty of water after meals
- Start 1-2 days before entering endemic area
Side Effect
- Urticaria
- serum sickness
- photosensitisation
- arthralgia
- nausea
- vomiting
- abdominal pain
- diarrhoea
- headache
- peripheral neuritis
- ataxia
- tinnitus
- vertigo
- convulsions
- toxic nephrosis and pulmonary infiltrates resembling eosinophilic or allergic alveolitis
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- fulminant hepatic necrosis
- blood dyscrasias
- anaphylactoid reactions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Halofantrine, Chlorpromazine
|
Increased levels
|
|
Warfarin
|
Increased effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Impairment
|
Drug cannot be eliminated properly
|
|
Blood Dyscrasias
|
Can worsen blood disorders
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.